| Literature DB >> 14623006 |
R Jain1, A Sundram, S Lopez, G Neckermann, C Wu, C Hackbarth, D Chen, W Wang, N S Ryder, B Weidmann, D Patel, J Trias, R White, Z Yuan.
Abstract
We report the synthesis and biological activity of analogues of VRC3375 (N-hydroxy-3-R-butyl-3-[(2-S-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl]propionamide), an orally active peptide deformylase inhibitor. This study explores the structure-activity relationship of various chelator groups, alpha substituents, P(2)' and P(3)' substituents in order to achieve optimal antibacterial activity with minimal toxicity liability.Entities:
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Year: 2003 PMID： 14623006 DOI： 10.1016/j.bmcl.2003.07.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823