Literature DB >> 18082601

Variability and robustness in biomolecular systems.

Naama Barkai1, Ben-Zion Shilo.   

Abstract

The need to perform sophisticated information processing in an environment that is variable and noisy restricts the functional design of biological networks. We discuss several of the strategies that cells and multicellular organisms have evolved to deal with this demand.

Mesh：

Year:  2007        PMID： 18082601     DOI： 10.1016/j.molcel.2007.11.013

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  37 in total

1.  Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

Authors:  Malte Paulsen; Stefan Legewie; Roland Eils; Emil Karaulanov; Christof Niehrs
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-01       Impact factor: 11.205

2.  The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.

Authors:  Guillaume Thibault; Nurzian Ismail; Davis T W Ng
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

3.  Automated imaging with ScanLag reveals previously undetectable bacterial growth phenotypes.

Authors:  Irit Levin-Reisman; Orit Gefen; Ofer Fridman; Irine Ronin; David Shwa; Hila Sheftel; Nathalie Q Balaban
Journal:  Nat Methods       Date:  2010-08-01       Impact factor: 28.547

Review 4.  MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems.

Authors:  Héctor Herranz; Stephen M Cohen
Journal:  Genes Dev       Date:  2010-07-01       Impact factor: 11.361

5.  Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence.

Authors:  Eitan Rotem; Adiel Loinger; Irine Ronin; Irit Levin-Reisman; Chana Gabay; Noam Shoresh; Ofer Biham; Nathalie Q Balaban
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-28       Impact factor: 11.205

6.  A two-step patterning process increases the robustness of periodic patterning in the fly eye.

Authors:  Avishai Gavish; Naama Barkai
Journal:  J Biol Phys       Date:  2016-02-16       Impact factor: 1.365

Review 7.  We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.

Authors:  Alexander Loewer; Galit Lahav
Journal:  Curr Opin Genet Dev       Date:  2011-10-15       Impact factor: 5.578

8.  Genomes, proteomes, and the central dogma.

Authors:  Sarah Franklin; Thomas M Vondriska
Journal:  Circ Cardiovasc Genet       Date:  2011-10

9.  Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources.

Authors:  Gene-Wei Li; David Burkhardt; Carol Gross; Jonathan S Weissman
Journal:  Cell       Date:  2014-04-24       Impact factor: 41.582

Review 10.  From the stochasticity of molecular processes to the variability of synaptic transmission.

Authors:  Claire Ribrault; Ken Sekimoto; Antoine Triller
Journal:  Nat Rev Neurosci       Date:  2011-06-20       Impact factor: 34.870
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