| Literature DB >> 18082141 |
Nicoletta Guaragnella1, Lucia Antonacci, Sergio Giannattasio, Ersilia Marra, Salvatore Passarella.
Abstract
To investigate the role of catalase and superoxide dismutase (SOD) in the acetic acid (AA) induced yeast programmed cell death (AA-PCD), we compared Saccharomyces cerevisiae cells (C-Y) and cells individually over-expressing catalase T (CTT1-Y) and Cu,Zn-SOD (SOD1-Y) with respect to cell survival, hydrogen peroxide (H2O2) levels and enzyme activity as measured up to 200 min after AA treatment. AA-PCD does not occur in CTT1-Y, where H2O2 levels were lower than in C-Y and the over-expressed catalase activity decreased with time. In SOD1-Y, AA-PCD was exacerbated; high H2O2 levels were found, SOD activity increased early, remaining constant en route to AA-PCD, but catalase activity was strongly reduced.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18082141 DOI： 10.1016/j.febslet.2007.12.007
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124