Literature DB >> 22449970

Ycf1p attenuates basal level oxidative stress response in Saccharomyces cerevisiae.

Christian M Paumi1, Kerry A Pickin, Roaa Jarrar, Catherine K Herren, Stuart T Cowley.   

Abstract

Ycf1p function is regulated by casein kinase 2α, Cka1p, via phosphorylation of Ser251. Cka1p-mediated phosphorylation of Ycf1p is attenuated in response to high salt stress. Previous results from our lab suggest a role for Ycf1p in cellular resistance to salt stress. Here, we show that Ycf1p plays an important role in cellular resistance to salt stress by maintaining the cellular redox balance via glutathione recycling. Our results suggest that during acute salt stress increased Sod1p, Sod2p and Ctt1p activity is the main compensatory for the loss in Ycf1p function that results from reduced Ycf1p-dependent recycling of cellular GSH levels. Copyright Â
© 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22449970      PMCID： PMC3314243          DOI： 10.1016/j.febslet.2012.02.010

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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