Literature DB >> 18077163

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

Berin A Boughton1, Renwick C J Dobson, Juliet A Gerrard, Craig A Hutton.   

Abstract

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyses the condensation of (S)-aspartate semi-aldehyde (ASA) and pyruvate to form dihydrodipicolinate. Constrained diketopimelic acid derivatives have been designed as mimics of the acyclic enzyme-bound condensation product of ASA and pyruvate. Several of the compounds are shown to be active, slow-binding inhibitors with improved inhibition of DHDPS.

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Year:  2007        PMID： 18077163     DOI： 10.1016/j.bmcl.2007.11.108

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera.

Authors:  Sarah C Atkinson; Con Dogovski; Janet Newman; Renwick C J Dobson; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-11-25

2.  Crystallization and preliminary X-ray diffraction analysis of L,L-diaminopimelate aminotransferase (DapL) from Chlamydomonas reinhardtii.

Authors:  André O Hudson; Irma Girón; Renwick C J Dobson
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-12-24

3.  Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana.

Authors:  Michael D W Griffin; Jagan M Billakanti; Juliet A Gerrard; Renwick C J Dobson; F Grant Pearce
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-10-27

4.  The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution.

Authors:  Ali R Cala; Maria T Nadeau; Jan Abendroth; Bart L Staker; Alexandra R Reers; Anthony W Weatherhead; Renwick C J Dobson; Peter J Myler; André O Hudson
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2016-11-25       Impact factor: 1.056

5.  The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana.

Authors:  Michael R Oliver; Jennifer M Crowther; Mary M Leeman; Sarah A Kessans; Rachel A North; Katherine A Donovan; Michael D W Griffin; Hironori Suzuki; André O Hudson; Müge Kasanmascheff; Renwick C J Dobson
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-04-25       Impact factor: 1.056

6.  The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.

Authors:  Sean R A Devenish; Juliet A Gerrard; Geoffrey B Jameson; Renwick C J Dobson
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-11-28

7.  Kinetic, spectral, and structural studies of the slow-binding inhibition of the Escherichia coli dihydrodipicolinate synthase by 2, 4-oxo-pentanoic acid.

Authors:  William Karsten; Leonard M Thomas; Christian Fleming; Priscilla Seabourn; Christina Bruxvoort; Lilian Chooback
Journal:  Arch Biochem Biophys       Date:  2021-02-24       Impact factor: 4.013

8.  L,L-diaminopimelate aminotransferase from Chlamydomonas reinhardtii: a target for algaecide development.

Authors:  Renwick C J Dobson; Irma Girón; André O Hudson
Journal:  PLoS One       Date:  2011-05-25       Impact factor: 3.240

9.  Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues.

Authors:  Priyanka Shrivastava; Vikas Navratna; Yumnam Silla; Rikeshwer P Dewangan; Atreyi Pramanik; Sarika Chaudhary; GeethaVani Rayasam; Anuradha Kumar; Balasubramanian Gopal; Srinivasan Ramachandran
Journal:  Sci Rep       Date:  2016-08-09       Impact factor: 4.379

10.  Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in response to different nutrients.

Authors:  Zhenglong Wang; Kai Jin; Yuxian Xia
Journal:  BMC Genomics       Date:  2016-08-09       Impact factor: 3.969
  10 in total

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