| Literature DB >> 18063364 |
Xiaohui Du1, Xiaoqi Chen, Jeffrey T Mihalic, Jeffrey Deignan, Jason Duquette, An-Rong Li, Bryan Lemon, Ji Ma, Shichang Miao, Karen Ebsworth, Timothy J Sullivan, George Tonn, Tassie L Collins, Julio C Medina.
Abstract
A series of imidazole derivatives have been designed and optimized for CXCR3 antagonism, pharmacokinetic properties, and reduced formation of glutathione conjugates. Our efforts led to the discovery of potent CXCR3 antagonists with good pharmacokinetic properties. These compounds are useful tools for in vivo studies of CXCR3 function.Entities:
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Year: 2007 PMID： 18063364 DOI： 10.1016/j.bmcl.2007.11.072
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823