Literature DB >> 24249661

Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones.

Elizabeth O'Bryan McCusker1, Karl A Scheidt.   

Abstract

Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  N-heterocyclic carbenes; asymmetric synthesis; catalysis; enals; organocatalysis

Mesh：

Substances：

Year:  2013        PMID： 24249661      PMCID： PMC3905989          DOI： 10.1002/anie.201307292

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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