Literature DB >> 18061679

Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine.

Jill M Kolesar1, William R Schelman, Peter G Geiger, Kyle D Holen, Anne M Traynor, Dona B Alberti, James P Thomas, Christopher R Chitambar, George Wilding, William E Antholine.   

Abstract

The metal chelator Triapine, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, is a potent inhibitor of ribonucleotide reductase. EPR spectra consistent with signals from Fe-transferrin, heme, and low-spin iron or cupric ion were observed in peripheral blood mononuclear cells (PBMCs) obtained from patients treated with Triapine. One signal that is unequivocally identified is the signal for Fe-transferrin. It is hypothesized that Fe uptake is blocked by reactive oxygen species generated by FeT(2) or CuT that damage transferrin or transferrin receptor. A potential source for the increase in the heme signal is cytochrome c released from the mitochondria. These results provide valuable insight into the in vivo mechanism of action of Triapine.

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Year:  2007        PMID： 18061679      PMCID： PMC2390869          DOI： 10.1016/j.jinorgbio.2007.10.013

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  20 in total

1.  Cytochrome c release from mitochondria: all or nothing.

Authors:  J C Martinou; S Desagher; B Antonsson
Journal:  Nat Cell Biol       Date:  2000-03       Impact factor: 28.824

2.  Effect of chelating agents upon the synthesis of nucleic acids and protein: inhibition of DNA synthesis by 1-formylisoquinoline thiosemicarbazone.

Authors:  A C Sartorelli
Journal:  Biochem Biophys Res Commun       Date:  1967-04-07       Impact factor: 3.575

3.  Three-dimensional structure of the free radical protein of ribonucleotide reductase.

Authors:  P Nordlund; B M Sjöberg; H Eklund
Journal:  Nature       Date:  1990-06-14       Impact factor: 49.962

4.  Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.

Authors:  Des R Richardson; Philip C Sharpe; David B Lovejoy; Dakshita Senaratne; Danuta S Kalinowski; Mohammad Islam; Paul V Bernhardt
Journal:  J Med Chem       Date:  2006-11-02       Impact factor: 7.446

Review 5.  Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

Authors:  Yu Yu; Jacky Wong; David B Lovejoy; Danuta S Kalinowski; Des R Richardson
Journal:  Clin Cancer Res       Date:  2006-12-01       Impact factor: 12.531

6.  A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.

Authors:  Megan Whitnall; Jonathan Howard; Prem Ponka; Des R Richardson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-26       Impact factor: 11.205

7.  Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells.

Authors:  Ayesha B Alvero; Wei Chen; Alan C Sartorelli; Peter Schwartz; Thomas Rutherford; Gil Mor
Journal:  J Soc Gynecol Investig       Date:  2006-02

8.  Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.

Authors:  Timothy B Chaston; David B Lovejoy; Ralph N Watts; Des R Richardson
Journal:  Clin Cancer Res       Date:  2003-01       Impact factor: 12.531

9.  Inhibition of iron uptake in HL60 cells by 2-formylpyridine monothiosemicarbazonato Cu(II).

Authors:  J Narasimhan; W E Antholine; C R Chitambar; D H Petering
Journal:  Arch Biochem Biophys       Date:  1991-09       Impact factor: 4.013

10.  A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase.

Authors:  Jimin Shao; Bingsen Zhou; Angel J Di Bilio; Lijun Zhu; Tieli Wang; Christina Qi; Jennifer Shih; Yun Yen
Journal:  Mol Cancer Ther       Date:  2006-03       Impact factor: 6.261
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  8 in total

1.  Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in cancer patients.

Authors:  Jill Kolesar; Richard C Brundage; Marcia Pomplun; Dona Alberti; Kyle Holen; Anne Traynor; Percy Ivy; George Wilding
Journal:  Cancer Chemother Pharmacol       Date:  2010-05-04       Impact factor: 3.333

2.  Cytotoxic Evaluation of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, 3-AP, in Peripheral Blood Lymphocytes of Patients with Refractory Solid Tumors using Electron Paramagnetic Resonance.

Authors:  Jill M Kolesar; Kamakshi Sachidanandam; William R Schelman; Jens Eickhoff; Kyle D Holen; Anne M Traynor; Dona B Alberti; James P Thomas; Christopher R Chitambar; George Wilding; William E Antholine
Journal:  Exp Ther Med       Date:  2011-01       Impact factor: 2.447

3.  Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs.

Authors:  Daniel Sun; Juno Van Valkenburgh; Sheba Plamthottam; Jeffrey Valenzuela; Bastian Ruehle; Dalton Steele; Soumya Poddar; Maxim Marshalik; Selena Hernandez; Caius Gabriel Radu; Jeffrey I Zink
Journal:  J Biol Inorg Chem       Date:  2019-06-27       Impact factor: 3.358

Review 4.  Harnessing microbial iron chelators to develop innovative therapeutic agents.

Authors:  Marta Ribeiro; Cátia A Sousa; Manuel Simões
Journal:  J Adv Res       Date:  2021-11-01       Impact factor: 12.822

Review 5.  Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.

Authors:  Christopher R Chitambar; William E Antholine
Journal:  Antioxid Redox Signal       Date:  2012-10-03       Impact factor: 8.401

6.  Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping.

Authors:  Judith M Myers; Qing Cheng; William E Antholine; Balaraman Kalyanaraman; Aleksandra Filipovska; Elias S J Arnér; Charles R Myers
Journal:  Free Radic Biol Med       Date:  2013-02-26       Impact factor: 7.376

7.  Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.

Authors:  Yimon Aye; Marcus J C Long; JoAnne Stubbe
Journal:  J Biol Chem       Date:  2012-08-22       Impact factor: 5.157

8.  EPR Study of Iron Ion Complexes in Human Blood.

Authors:  Ryszard Krzyminiewski; Zdzisław Kruczyński; Bernadeta Dobosz; Anna Zając; Andrzej Mackiewicz; Ewa Leporowska; Sandra Folwaczna
Journal:  Appl Magn Reson       Date:  2011-04-05       Impact factor: 0.831
  8 in total

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