Literature DB >> 2190093

Three-dimensional structure of the free radical protein of ribonucleotide reductase.

P Nordlund1, B M Sjöberg, H Eklund.   

Abstract

The enzyme ribonucleotide reductase furnishes precursors for the DNA synthesis of all living cells. One of its constituents, the free radical protein, has an unusual alpha-helical structure. There are two iron centres that are about 25 A apart in the dimeric molecule. Tyrosine 122, which harbours the stable free radical necessary for the activity of ribonucleotide reductase, is buried inside the protein and is located 5 A from the closest iron atom.

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Year:  1990        PMID： 2190093     DOI： 10.1038/345593a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  132 in total

1.  Radiation inactivation of ribonucleotide reductase, an enzyme with a stable free radical.

Authors:  G Bolger; M Liuzzi; R Krogsrud; E Scouten; R McCollum; E Welchner; E Kempner
Journal:  Biophys J       Date:  2000-10       Impact factor: 4.033

2.  Ribonucleotide reductase genes of Bacillus prophages: a refuge to introns and intein coding sequences.

Authors:  V Lazarevic
Journal:  Nucleic Acids Res       Date:  2001-08-01       Impact factor: 16.971

3.  Structure of the N-terminal region of Haemophilus influenzae H10017: implications for function.

Authors:  L Yu; J Mack; P Hajduk; S W Fesik
Journal:  J Biomol NMR       Date:  2001-06       Impact factor: 2.835

4.  Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation.

Authors:  Liv J Rather; Bettina Knapp; Wolfgang Haehnel; Georg Fuchs
Journal:  J Biol Chem       Date:  2010-05-07       Impact factor: 5.157

5.  Proton Coupled Electron Transfer and Redox Active Tyrosines: Structure and Function of the Tyrosyl Radicals in Ribonucleotide Reductase and Photosystem II.

Authors:  Bridgette A Barry; Jun Chen; James Keough; David Jenson; Adam Offenbacher; Cynthia Pagba
Journal:  J Phys Chem Lett       Date:  2012-02-08       Impact factor: 6.475

6.  Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.

Authors:  Nozomi Ando; Edward J Brignole; Christina M Zimanyi; Michael A Funk; Kenichi Yokoyama; Francisco J Asturias; Joanne Stubbe; Catherine L Drennan
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-12       Impact factor: 11.205

7.  Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.

Authors:  Yan Zhang; Lili Liu; Xiaorong Wu; Xiuxiang An; JoAnne Stubbe; Mingxia Huang
Journal:  J Biol Chem       Date:  2011-09-19       Impact factor: 5.157

Review 8.  Assembly of nonheme Mn/Fe active sites in heterodinuclear metalloproteins.

Authors:  Julia J Griese; Vivek Srinivas; Martin Högbom
Journal:  J Biol Inorg Chem       Date:  2014-04-26       Impact factor: 3.358

Review 9.  Proton-Coupled Electron Transfer in Organic Synthesis: Fundamentals, Applications, and Opportunities.

Authors:  David C Miller; Kyle T Tarantino; Robert R Knowles
Journal:  Top Curr Chem (Cham)       Date:  2016-05-09

10.  In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.

Authors:  Yoo Seong Choi; Houjin Zhang; Joseph S Brunzelle; Satish K Nair; Huimin Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-05       Impact factor: 11.205
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