Literature DB >> 18060019

Chemical modification: the key to clinical application of RNA interference?

David R Corey1.   

Abstract

RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.

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Year:  2007        PMID： 18060019      PMCID： PMC2096450          DOI： 10.1172/JCI33483

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  81 in total

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Authors:  Dwaine A Braasch; Susan Jensen; Yinghui Liu; Kiran Kaur; Khalil Arar; Michael A White; David R Corey
Journal:  Biochemistry       Date:  2003-07-08       Impact factor: 3.162

Review 2.  Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.

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3.  Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

Authors:  Charles R Allerson; Namir Sioufi; Russell Jarres; Thazha P Prakash; Nishant Naik; Andres Berdeja; Lisa Wanders; Richard H Griffey; Eric E Swayze; Balkrishen Bhat
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4.  Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.

Authors:  James O McNamara; Eran R Andrechek; Yong Wang; Kristi D Viles; Rachel E Rempel; Eli Gilboa; Bruce A Sullenger; Paloma H Giangrande
Journal:  Nat Biotechnol       Date:  2006-06-25       Impact factor: 54.908

5.  Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

Authors:  Prasad Dande; Thazha P Prakash; Namir Sioufi; Hans Gaus; Russell Jarres; Andreas Berdeja; Eric E Swayze; Richard H Griffey; Balkrishen Bhat
Journal:  J Med Chem       Date:  2006-03-09       Impact factor: 7.446

6.  Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides.

Authors:  R S Geary; R Z Yu; A A Levin
Journal:  Curr Opin Investig Drugs       Date:  2001-04

7.  Biodistribution and metabolism of a mixed backbone oligonucleotide (GEM 231) following single and multiple dose administration in mice.

Authors:  M Rusckowski; T Qu; A Roskey; S Agrawal
Journal:  Antisense Nucleic Acid Drug Dev       Date:  2000-10

8.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Authors:  Jürgen Soutschek; Akin Akinc; Birgit Bramlage; Klaus Charisse; Rainer Constien; Mary Donoghue; Sayda Elbashir; Anke Geick; Philipp Hadwiger; Jens Harborth; Matthias John; Venkitasamy Kesavan; Gary Lavine; Rajendra K Pandey; Timothy Racie; Kallanthottathil G Rajeev; Ingo Röhl; Ivanka Toudjarska; Gang Wang; Silvio Wuschko; David Bumcrot; Victor Koteliansky; Stefan Limmer; Muthiah Manoharan; Hans-Peter Vornlocher
Journal:  Nature       Date:  2004-11-11       Impact factor: 49.962

9.  Competition for RISC binding predicts in vitro potency of siRNA.

Authors:  Erich Koller; Stephanie Propp; Heather Murray; Walter Lima; Balkrishen Bhat; Thaza P Prakash; Charles R Allerson; Eric E Swayze; Eric G Marcusson; Nicholas M Dean
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10.  Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque.

Authors:  Bao-jian Li; Qingquan Tang; Du Cheng; Chuan Qin; Frank Y Xie; Qiang Wei; Jun Xu; Yijia Liu; Bo-jian Zheng; Martin C Woodle; Nanshan Zhong; Patrick Y Lu
Journal:  Nat Med       Date:  2005-08-21       Impact factor: 53.440
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  83 in total

1.  Monomers for preparation of amide linked RNA: Synthesis of C3'-homologated nucleoside amino acids from d-xylose.

Authors:  Paul Tanui; Martin Kullberg; Ni Song; Yashodhan Chivate; Eriks Rozners
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Review 2.  Silencing disease genes in the laboratory and the clinic.

Authors:  Jonathan K Watts; David R Corey
Journal:  J Pathol       Date:  2011-11-09       Impact factor: 7.996

Review 3.  Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

Authors:  Dirk Grimm; Mark A Kay
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5.  LNA-based oligonucleotide electrotransfer for miRNA inhibition.

Authors:  Sophie Chabot; Julie Orio; Romain Castanier; Elisabeth Bellard; Søren J Nielsen; Muriel Golzio; Justin Teissié
Journal:  Mol Ther       Date:  2012-05-22       Impact factor: 11.454

Review 6.  The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine.

Authors:  Alireza Majdi; Javad Mahmoudi; Saeed Sadigh-Eteghad; Mehdi Farhoudi; Siamak Sandoghchian Shotorbani
Journal:  Neurol Sci       Date:  2016-06-27       Impact factor: 3.307

7.  Design and assessment of engineered CRISPR-Cpf1 and its use for genome editing.

Authors:  Bin Li; Chunxi Zeng; Yizhou Dong
Journal:  Nat Protoc       Date:  2018-04-05       Impact factor: 13.491

8.  Telomeres and telomerase: from discovery to clinical trials.

Authors:  David R Corey
Journal:  Chem Biol       Date:  2009-12-24

9.  Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

Authors:  Uday Ghanty; Erik Fostvedt; Rachel Valenzuela; Peter A Beal; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

10.  MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer.

Authors:  Nuo Yang; Sippy Kaur; Stefano Volinia; Joel Greshock; Heini Lassus; Kosei Hasegawa; Shun Liang; Arto Leminen; Shan Deng; Lori Smith; Cameron N Johnstone; Xian-Ming Chen; Chang-Gong Liu; Qihong Huang; Dionyssios Katsaros; George Adrian Calin; Barbara L Weber; Ralf Bützow; Carlo M Croce; George Coukos; Lin Zhang
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701
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