Literature DB >> 27350638

The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine.

Alireza Majdi1, Javad Mahmoudi2, Saeed Sadigh-Eteghad1, Mehdi Farhoudi1, Siamak Sandoghchian Shotorbani3.   

Abstract

Stroke is the second leading cause of death and the most common cause of adult disabilities among elderlies. It involves a complex series of mechanisms among which, excitotoxicity is of great importance. Also, miRNAs appear to play role in post-stroke excitotoxicity, and changes in their transcriptome occur right after cerebral ischemia. Recent data indicate that specific miRNAs such as miRNA-223, miRNA-181, miRNA-125a, miRNA-125b, miRNA-1000, miRNA-132 and miRNA-124a regulate glutamate neurotransmission and excitotoxicity during stroke. However, limitations such as poor in vivo stability, side effects and inappropriate biodistribution in miRNA-based therapies still exist and should be overcome before clinical application. Thence, investigation of the effect of application of these miRNAs after the onset of ischemia is a pivotal step for manipulating these miRNAs in clinical use. Given this, present review concentrates on miRNAs roles in post-ischemic stroke excitotoxicity.

Entities:  

Keywords:  AMPA receptors; Glutamate excitotoxicity; Ischemic stroke; MicroRNA; NMDA receptors

Mesh：

Substances：

Year:  2016        PMID： 27350638     DOI： 10.1007/s10072-016-2643-5

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  77 in total

1.  Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes.

Authors:  Emmette R Hutchison; Elisa M Kawamoto; Dennis D Taub; Ashish Lal; Kotb Abdelmohsen; Yongqing Zhang; William H Wood; Elin Lehrmann; Simonetta Camandola; Kevin G Becker; Myriam Gorospe; Mark P Mattson
Journal:  Glia       Date:  2013-05-07       Impact factor: 7.452

2.  miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.

Authors:  Yi-Bing Ouyang; Yu Lu; Sibiao Yue; Li-Jun Xu; Xiao-Xing Xiong; Robin E White; Xiaoyun Sun; Rona G Giffard
Journal:  Neurobiol Dis       Date:  2011-09-24       Impact factor: 5.996

3.  MicroRNAs induced during ischemic preconditioning.

Authors:  Soon-Tae Lee; Kon Chu; Keun-Hwa Jung; Hye-Jin Yoon; Daejong Jeon; Kyoung-Mook Kang; Ki-Ho Park; Eun-Kee Bae; Manho Kim; Sang Kun Lee; Jae-Kyu Roh
Journal:  Stroke       Date:  2010-06-24       Impact factor: 7.914

Review 4.  Progress in microRNA delivery.

Authors:  Yu Zhang; Zaijie Wang; Richard A Gemeinhart
Journal:  J Control Release       Date:  2013-09-25       Impact factor: 9.776

Review 5.  Advances in astrocyte-targeted approaches for stroke therapy: an emerging role for mitochondria and microRNAS.

Authors:  Creed M Stary; Rona G Giffard
Journal:  Neurochem Res       Date:  2014-07-04       Impact factor: 3.996

Review 6.  microRNA: emerging therapeutic targets in acute ischemic diseases.

Authors:  Pasquale Fasanaro; Simona Greco; Mircea Ivan; Maurizio C Capogrossi; Fabio Martelli
Journal:  Pharmacol Ther       Date:  2009-11-06       Impact factor: 12.310

Review 7.  MicroRNAs (miRNAs) in neurodegenerative diseases.

Authors:  Peter T Nelson; Wang-Xia Wang; Bernard W Rajeev
Journal:  Brain Pathol       Date:  2008-01       Impact factor: 6.508

8.  MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion.

Authors:  Kandiah Jeyaseelan; Kai Ying Lim; Arunmozhiarasi Armugam
Journal:  Stroke       Date:  2008-02-07       Impact factor: 7.914

9.  Increase of circulating miR-223 and insulin-like growth factor-1 is associated with the pathogenesis of acute ischemic stroke in patients.

Authors:  Yang Wang; Yu Zhang; Jun Huang; Xiaoyan Chen; Xiang Gu; Yongting Wang; Lili Zeng; Guo-Yuan Yang
Journal:  BMC Neurol       Date:  2014-04-08       Impact factor: 2.474

Review 10.  Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases.

Authors:  Howard Prentice; Jigar Pravinchandra Modi; Jang-Yen Wu
Journal:  Oxid Med Cell Longev       Date:  2015-10-20       Impact factor: 6.543
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  12 in total

1.  Circulating miR-126 and miR-130a levels correlate with lower disease risk, disease severity, and reduced inflammatory cytokine levels in acute ischemic stroke patients.

Authors:  Fuqiang Jin; Jie Xing
Journal:  Neurol Sci       Date:  2018-07-20       Impact factor: 3.307

2.  Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke.

Authors:  Sanam Dolati; Majid Ahmadi; Mohammad Khalili; Ali Akabar Taheraghdam; Homayoon Siahmansouri; Zohreh Babaloo; Leili Aghebati-Maleki; Farhad Jadidi-Niaragh; Vahid Younesi; Mehdi Yousefi
Journal:  Neurol Sci       Date:  2018-01-20       Impact factor: 3.307

Review 3.  MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer.

Authors:  Jakub Godlewski; Jacek Lenart; Elzbieta Salinska
Journal:  Noncoding RNA       Date:  2019-02-23

Review 4.  Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis.

Authors:  Metka Ravnik-Glavač; Damjan Glavač
Journal:  Int J Mol Sci       Date:  2020-03-03       Impact factor: 5.923

5.  Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway.

Authors:  Kun Hou; Guichen Li; Jinchuan Zhao; Baofeng Xu; Yang Zhang; Jinlu Yu; Kan Xu
Journal:  J Neuroinflammation       Date:  2020-02-03       Impact factor: 8.322

6.  miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.

Authors:  Li Zhu; Xueying Zhou; Shanshan Li; Jianmeng Liu; Jingyan Yang; Xiangyun Fan; Shengnian Zhou
Journal:  Mol Med Rep       Date:  2020-09-07       Impact factor: 2.952

7.  Low expression of miR‑532‑3p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2.

Authors:  Li Mao; Mei-Ling Zuo; Ai-Ping Wang; Ying Tian; Li-Chen Dong; Tao-Ming Li; Da-Bin Kuang; Gui-Lin Song; Zhong-Bao Yang
Journal:  Mol Med Rep       Date:  2020-07-10       Impact factor: 2.952

Review 8.  Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia.

Authors:  Lu Lian; Yunsha Zhang; Lu Liu; Liji Yang; Yichen Cai; Junping Zhang; Shixin Xu
Journal:  Front Mol Neurosci       Date:  2021-01-07       Impact factor: 5.639

9.  Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model.

Authors:  Vitaly A Selivanov; Olga A Zagubnaya; Yaroslav R Nartsissov; Marta Cascante
Journal:  PLoS One       Date:  2021-08-03       Impact factor: 3.240

10.  Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes.

Authors:  J Rzemieniec; E Bratek; A Wnuk; K Przepiórska; E Salińska; M Kajta
Journal:  Apoptosis       Date:  2020-08-20       Impact factor: 4.677
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