Literature DB >> 18057543

Genetically engineered rat models for breast cancer.

Bart M G Smits1, Michelle S Cotroneo, Jill D Haag, Michael N Gould.   

Abstract

Rat mammary cancers generally resemble many features of human breast cancer. With the recent developments in rat genetic engineering, the rat has become an excellent model system to study aspects of the molecular etiology of breast cancer. In this review, we describe the efforts to generate genetically engineered rat models for breast cancer.

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Year:  2007        PMID： 18057543     DOI： 10.3233/bd-2007-28106

Source DB:  PubMed          Journal:  Breast Dis        ISSN： 0888-6008


  9 in total

1.  Generating gene knockout rats by homologous recombination in embryonic stem cells.

Authors:  Chang Tong; Guanyi Huang; Charles Ashton; Ping Li; Qi-Long Ying
Journal:  Nat Protoc       Date:  2011-05-26       Impact factor: 13.491

2.  Homology models of mouse and rat estrogen receptor-α ligand-binding domain created by in silico mutagenesis of a human template: molecular docking with 17ß-estradiol, diethylstilbestrol, and paraben analogs.

Authors:  Thomas L Gonzalez; James M Rae; Justin A Colacino; Rudy J Richardson
Journal:  Comput Toxicol       Date:  2018-11-28

Review 3.  How can grafted breast cancer models be optimized?

Authors:  Séverine Mollard; Yoanne Mousseau; Yasser Baaj; Laurence Richard; Jeanne Cook-Moreau; Jacques Monteil; Benoît Funalot; Franck G Sturtz
Journal:  Cancer Biol Ther       Date:  2011-11-15       Impact factor: 4.742

4.  Pathologic progression of mammary carcinomas in a C3(1)/SV40 T/t-antigen transgenic rat model of human triple-negative and Her2-positive breast cancer.

Authors:  M J Hoenerhoff; M A Shibata; A Bode; J E Green
Journal:  Transgenic Res       Date:  2010-06-12       Impact factor: 2.788

5.  Beyond knockout rats: new insights into finer genome manipulation in rats.

Authors:  Guanyi Huang; Chang Tong; Dhruv S Kumbhani; Charles Ashton; Hexin Yan; Qi-Long Ying
Journal:  Cell Cycle       Date:  2011-04-01       Impact factor: 4.534

6.  Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene.

Authors:  Xuefeng Ren; Jessica C Graham; Lichen Jing; Andrei M Mikheev; Yuan Gao; Jenny Pan Lew; Hong Xie; Andrea S Kim; Xiuling Shang; Cynthia Friedman; Graham Vail; Ming Zhu Fang; Yana Bromberg; Helmut Zarbl
Journal:  PLoS One       Date:  2013-09-02       Impact factor: 3.240

7.  Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.

Authors:  Mingzhu Fang; Pamela A Ohman Strickland; Hwan-Goo Kang; Helmut Zarbl
Journal:  Oncotarget       Date:  2017-05-16

8.  lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p.

Authors:  Yi Peng; Xiaoxi Huang; Hongmei Wang
Journal:  BMC Mol Cell Biol       Date:  2022-07-27

9.  Brca1L63X /+ rat is a novel model of human BRCA1 deficiency displaying susceptibility to radiation-induced mammary cancer.

Authors:  Yuzuki Nakamura; Jo Kubota; Yukiko Nishimura; Kento Nagata; Mayumi Nishimura; Kazuhiro Daino; Atsuko Ishikawa; Takehito Kaneko; Tomoji Mashimo; Toshiaki Kokubo; Masaru Takabatake; Kazumasa Inoue; Masahiro Fukushi; Masami Arai; Mitsue Saito; Yoshiya Shimada; Shizuko Kakinuma; Tatsuhiko Imaoka
Journal:  Cancer Sci       Date:  2022-08-21       Impact factor: 6.518
  9 in total

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