RATIONALE: Recent studies indicate that Adult Separation Anxiety Disorder (ASAD) may represent a discrete diagnostic entity worthy of attention. Adults with separation anxiety report extreme anxiety and fear about separations from major attachment figures (partner, children or parents). These symptoms affect individual's behavior, lead to severe impairment in social relationships and are not better accounted for by the presence of agoraphobia. In a previous study we found platelet expression reduction of the 18 kDa Translocator Protein (TSPO) (the new nomenclature for the peripheral-type benzodiazepine receptor) in patients with panic disorder who also fulfilled the diagnostic criteria for ASAD. OBJECTIVES: To explore whether separation anxiety might be a factor differentiating TSPO expression in a sample of patients with major depression. METHODS: The equilibrium binding parameters of the specific TSPO ligand [3H]PK 11195 were estimated on platelet membranes from 40 adult outpatients with DSM-IV diagnosis of MDD, with or without separation anxiety symptoms, and 20 healthy controls. Patients were assessed by SCID-I, HAM-D, the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS-A) and the Adult Separation Anxiety Self-report Checklist (ASA-27). RESULTS: A significant reduction of platelet TSPO density mean value was found in depressed patients with associated ASAD symptoms, while no significant differences were found between depressed patients without ASAD and the control group. Individual TSPO density values were significantly and negatively correlated with both SCI-SAS-A and ASA-27 total scores, but not with HAM-D total score or HAM-D anxiety/somatization factor score. CONCLUSIONS: The reduction of platelet TSPO density in our sample of patients with depression was specifically related to the presence of ASAD. These data suggest that TSPO expression evaluation is a useful biological marker of ASAD.
RATIONALE: Recent studies indicate that Adult Separation Anxiety Disorder (ASAD) may represent a discrete diagnostic entity worthy of attention. Adults with separation anxiety report extreme anxiety and fear about separations from major attachment figures (partner, children or parents). These symptoms affect individual's behavior, lead to severe impairment in social relationships and are not better accounted for by the presence of agoraphobia. In a previous study we found platelet expression reduction of the 18 kDa Translocator Protein (TSPO) (the new nomenclature for the peripheral-type benzodiazepine receptor) in patients with panic disorder who also fulfilled the diagnostic criteria for ASAD. OBJECTIVES: To explore whether separation anxiety might be a factor differentiating TSPO expression in a sample of patients with major depression. METHODS: The equilibrium binding parameters of the specific TSPO ligand [3H]PK 11195 were estimated on platelet membranes from 40 adult outpatients with DSM-IV diagnosis of MDD, with or without separation anxiety symptoms, and 20 healthy controls. Patients were assessed by SCID-I, HAM-D, the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS-A) and the Adult Separation Anxiety Self-report Checklist (ASA-27). RESULTS: A significant reduction of platelet TSPO density mean value was found in depressedpatients with associated ASAD symptoms, while no significant differences were found between depressedpatients without ASAD and the control group. Individual TSPO density values were significantly and negatively correlated with both SCI-SAS-A and ASA-27 total scores, but not with HAM-D total score or HAM-D anxiety/somatization factor score. CONCLUSIONS: The reduction of platelet TSPO density in our sample of patients with depression was specifically related to the presence of ASAD. These data suggest that TSPO expression evaluation is a useful biological marker of ASAD.
Authors: Borwin Bandelow; David Baldwin; Marianna Abelli; Blanca Bolea-Alamanac; Michel Bourin; Samuel R Chamberlain; Eduardo Cinosi; Simon Davies; Katharina Domschke; Naomi Fineberg; Edna Grünblatt; Marek Jarema; Yong-Ku Kim; Eduard Maron; Vasileios Masdrakis; Olya Mikova; David Nutt; Stefano Pallanti; Stefano Pini; Andreas Ströhle; Florence Thibaut; Matilde M Vaghi; Eunsoo Won; Dirk Wedekind; Adam Wichniak; Jade Woolley; Peter Zwanzger; Peter Riederer Journal: World J Biol Psychiatry Date: 2016-07-15 Impact factor: 4.132
Authors: Victor W Pike; Sabrina Taliani; Talakad G Lohith; David R J Owen; Isabella Pugliesi; Eleonora Da Pozzo; Jinsoo Hong; Sami S Zoghbi; Roger N Gunn; Christine A Parker; Eugenii A Rabiner; Masahiro Fujita; Robert B Innis; Claudia Martini; Federico Da Settimo Journal: J Med Chem Date: 2010-12-06 Impact factor: 7.446
Authors: Rainer Rupprecht; Vassilios Papadopoulos; Gerhard Rammes; Thomas C Baghai; Jinjiang Fan; Nagaraju Akula; Ghislaine Groyer; David Adams; Michael Schumacher Journal: Nat Rev Drug Discov Date: 2010-12 Impact factor: 84.694
Authors: Jonas Hannestad; Nicole DellaGioia; Jean-Dominique Gallezot; Keunpoong Lim; Nabeel Nabulsi; Irina Esterlis; Brian Pittman; Jae-Yun Lee; Kevin C O'Connor; Daniel Pelletier; Richard E Carson Journal: Brain Behav Immun Date: 2013-07-09 Impact factor: 7.217
Authors: Paolo Zanotti-Fregonara; Yi Zhang; Kimberly J Jenko; Robert L Gladding; Sami S Zoghbi; Masahiro Fujita; Gianluca Sbardella; Sabrina Castellano; Sabrina Taliani; Claudia Martini; Robert B Innis; Federico Da Settimo; Victor W Pike Journal: ACS Chem Neurosci Date: 2014-08-25 Impact factor: 4.418
Authors: Gino Pozzi; Angelo Bruschi; Andrea De Angelis; Marco Pascucci; Daniele Stavros Hatzigiakoumis; Paolo Grandinetti; Marco Di Nicola; Stefano Pini; Luigi Janiri Journal: Biomed Res Int Date: 2014-07-03 Impact factor: 3.411
Authors: Mark G MacAskill; Catriona Wimberley; Timaeus E F Morgan; Carlos J Alcaide-Corral; David E Newby; Christophe Lucatelli; Andrew Sutherland; Sally L Pimlott; Adriana A S Tavares Journal: Eur J Nucl Med Mol Imaging Date: 2021-08-02 Impact factor: 9.236