Literature DB >> 18052024

Allosteric modulation of the dopamine receptor by conformationally constrained type VI beta-turn peptidomimetics of Pro-Leu-Gly-NH2.

Ashish P Vartak1, Kevin Skoblenick, Nancy Thomas, Ram K Mishra, Rodney L Johnson.   

Abstract

A peptidomimetic of Pro-Leu-Pro-NH2, 7, possessing an indolizidinone type VI beta-turn mimic was synthesized via improved high-yielding protocols for the preparation and Cbz protection of alpha-allylproline. Bicyclic peptidomimetic 7 and spirobicylic peptidomimetic 8 enhanced the binding of [3H] N-propylnorapomorphine to dopamine receptors indicating that a type VI beta-turn is a possible bioactive conformation of the homochiral Pro-Leu-Pro-NH2 and Pro-Pro-Pro-NH 2 analogues of Pro-Leu-Gly-NH2 at the dopamine receptor allosteric regulatory site.

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Year:  2007        PMID： 18052024      PMCID： PMC2529021          DOI： 10.1021/jm070895r

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  23 in total

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Authors:  Ashish P Vartak; Rodney L Johnson
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Journal:  Gen Pharmacol       Date:  1982

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