Literature DB >> 6124481

The effects of prolyl-leucyl-glycine amide on drug-induced rotation in lesioned rats.

J R Smith, M Morgan.   

Abstract

1. The effects of L-prolyl-L-leucyl-glycine amide (PLG) on drug-induced rotational behavior were studied in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra. 2. Although PLG alone was found to be ineffective at inducing rotation in these animals, pretreatment with PLG at various doses was found to enhance both amphetamine and apomorphine-induced rotation. 3. This response proved to be biphasic with loss of activity in the higher dose ranges. 4. The pattern of effects observed suggests that PLG may act postsynaptically at a non-striatal site.

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Year:  1982        PMID： 6124481     DOI： 10.1016/0306-3623(82)90090-8

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  2 in total

1.  PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophrenia.

Authors:  Bailee Dyck; Kelly Guest; Christal Sookram; Dipannita Basu; Rodney Johnson; Ram K Mishra
Journal:  Schizophr Res       Date:  2010-10-30       Impact factor: 4.939

2.  Allosteric modulation of the dopamine receptor by conformationally constrained type VI beta-turn peptidomimetics of Pro-Leu-Gly-NH2.

Authors:  Ashish P Vartak; Kevin Skoblenick; Nancy Thomas; Ram K Mishra; Rodney L Johnson
Journal:  J Med Chem       Date:  2007-12-01       Impact factor: 7.446
  2 in total

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