Wahiba Sakly1, Moncef Jeddi, Ibtissem Ghedira. 1. Research Unit of Auto-immunity and Allergy (03UR/07-02), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
Abstract
AIM: The aim of this study was to evaluate, retrospectively, the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with primary biliary cirrhosis (PBC). METHODS: ASCA, IgG, and IgA, were determined by ELISA in sera of 95 PBC patients; 80 healthy blood donors served as controls. RESULTS: The frequency of ASCA (IgG or IgA) was significantly higher in PBC patients than in the control group (24.2% vs 3.7%, P = 0.0001). The frequency of ASCA IgG and ASCA IgA in PBC patients was also significantly higher than that found in the control group (18.9% vs 2.5%, P = 0.0006 and 11.6% vs 1.2%, P = 0.007, respectively). Six patients out of 95 (6.3%) had both ASCA IgG and ASCA IgA; in contrast, none of the control group had both isotypes (P = 0.02). There was no correlation between ASCA levels and mitochondrial autoantibodies (AMA) titres in PBC patients. CONCLUSION: We conclude that ASCA are common in patients with PBC.
AIM: The aim of this study was to evaluate, retrospectively, the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with primary biliary cirrhosis (PBC). METHODS: ASCA, IgG, and IgA, were determined by ELISA in sera of 95 PBC patients; 80 healthy blood donors served as controls. RESULTS: The frequency of ASCA (IgG or IgA) was significantly higher in PBC patients than in the control group (24.2% vs 3.7%, P = 0.0001). The frequency of ASCA IgG and ASCA IgA in PBC patients was also significantly higher than that found in the control group (18.9% vs 2.5%, P = 0.0006 and 11.6% vs 1.2%, P = 0.007, respectively). Six patients out of 95 (6.3%) had both ASCA IgG and ASCA IgA; in contrast, none of the control group had both isotypes (P = 0.02). There was no correlation between ASCA levels and mitochondrial autoantibodies (AMA) titres in PBC patients. CONCLUSION: We conclude that ASCA are common in patients with PBC.
Authors: A Granito; D Zauli; P Muratori; L Muratori; A Grassi; R Bortolotti; N Petrolini; L Veronesi; P Gionchetti; F B Bianchi; U Volta Journal: Aliment Pharmacol Ther Date: 2005-04-01 Impact factor: 8.171
Authors: Jan G M C Damoiseaux; Bas Bouten; Annick M L W Linders; Jos Austen; Caroline Roozendaal; Maurice G V M Russel; Pierre-Philippe Forget; Jan Willem Cohen Tervaert Journal: J Clin Immunol Date: 2002-09 Impact factor: 8.317
Authors: P Muratori; L Muratori; M Guidi; S Maccariello; G Pappas; R Ferrari; P Gionchetti; M Campieri; F B Bianchi Journal: Clin Exp Immunol Date: 2003-06 Impact factor: 4.330