OBJECTIVES: To evaluate gastrointestinal permeability in primary biliary cirrhosis (PBC), using a sensitive method to detect epithelial damage, and to correlate it with the Mayo score, histological stage, ascites, spontaneous bacterial peritonitis, endoscopic signs of portal hypertension and Helicobacter pylori infection. METHODS: Fifty consecutive patients with PBC and 39 patients with cirrhosis of other aetiologies (non-PBC) were enrolled in the study. Coeliac disease was initially ruled out in all participants. Permeability was assessed using sucrose (gastro-duodenum) and lactulose-mannitol (intestine). RESULTS: Sucrose excretion was above the limit in both PBC and non-PBC patients. Twenty-two per cent of PBC patients had an increased result for the lactulose-mannitol test compared to 12.8% of non-PBC cirrhotic patients. PBC patients had high sucrose excretion levels irrespective of the presence of any oesophageal varices, which significantly increased the gastroduodenal permeability in non-PBC patients only when associated with hypertensive gastropathy. Sucrose excretion was significantly enhanced by hypertensive gastropathy in non-PBC patients (P < 0.001) but not in PBC patients. No significant correlation was found in either group between gastrointestinal permeability and the other parameters. CONCLUSIONS: Gastrointestinal permeability is increased in PBC. Portal hypertension contributes to altered gastric mucosal permeability in non-PBC cirrhosis, whereas different epithelial dysfunction can be hypothesized in PBC.
OBJECTIVES: To evaluate gastrointestinal permeability in primary biliary cirrhosis (PBC), using a sensitive method to detect epithelial damage, and to correlate it with the Mayo score, histological stage, ascites, spontaneous bacterial peritonitis, endoscopic signs of portal hypertension and Helicobacter pylori infection. METHODS: Fifty consecutive patients with PBC and 39 patients with cirrhosis of other aetiologies (non-PBC) were enrolled in the study. Coeliac disease was initially ruled out in all participants. Permeability was assessed using sucrose (gastro-duodenum) and lactulose-mannitol (intestine). RESULTS:Sucrose excretion was above the limit in both PBC and non-PBCpatients. Twenty-two per cent of PBCpatients had an increased result for the lactulose-mannitol test compared to 12.8% of non-PBC cirrhotic patients. PBCpatients had high sucrose excretion levels irrespective of the presence of any oesophageal varices, which significantly increased the gastroduodenal permeability in non-PBCpatients only when associated with hypertensive gastropathy. Sucrose excretion was significantly enhanced by hypertensive gastropathy in non-PBCpatients (P < 0.001) but not in PBCpatients. No significant correlation was found in either group between gastrointestinal permeability and the other parameters. CONCLUSIONS:Gastrointestinal permeability is increased in PBC. Portal hypertension contributes to altered gastric mucosal permeability in non-PBCcirrhosis, whereas different epithelial dysfunction can be hypothesized in PBC.
Authors: John Almeida; Sumedha Galhenage; Jennifer Yu; Jelica Kurtovic; Stephen M Riordan Journal: World J Gastroenterol Date: 2006-03-14 Impact factor: 5.742
Authors: Anna Isaacs-Ten; Marta Echeandia; Mar Moreno-Gonzalez; Arlaine Brion; Andrew Goldson; Mark Philo; Angela M Patterson; Aimee Parker; Mikel Galduroz; David Baker; Simon M Rushbrook; Falk Hildebrand; Naiara Beraza Journal: Hepatology Date: 2020-12 Impact factor: 17.298
Authors: Marilia Rita Pinzone; Benedetto Maurizio Celesia; Michele Di Rosa; Bruno Cacopardo; Giuseppe Nunnari Journal: Int J Microbiol Date: 2012-07-17