OBJECTIVE: Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America. We aimed to determine whether this locus confers significant susceptibility to CAD in a South Korean population, and thus cross-race susceptibility to CAD. METHODS AND RESULTS: We performed a case-control association study with 611 unrelated CAD patients and 294 normal controls from South Korea. Allelic associations of SNPs and SNP haplotypes with CAD were evaluated. Multivariate logistic regression analysis was used to adjust effects of clinical covariates. We found that 4 SNPs on chromosome 9p21 were associated with susceptibility to CAD in a South Korean population. The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54). This represents the first study that expands association of these 9p21 SNPs with CAD beyond White populations. CONCLUSIONS: Chromosome 9p21 is an important susceptibility locus that confers high cross-race risk for development of CAD.
OBJECTIVE: Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America. We aimed to determine whether this locus confers significant susceptibility to CAD in a South Korean population, and thus cross-race susceptibility to CAD. METHODS AND RESULTS: We performed a case-control association study with 611 unrelated CAD patients and 294 normal controls from South Korea. Allelic associations of SNPs and SNP haplotypes with CAD were evaluated. Multivariate logistic regression analysis was used to adjust effects of clinical covariates. We found that 4 SNPs on chromosome 9p21 were associated with susceptibility to CAD in a South Korean population. The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54). This represents the first study that expands association of these 9p21 SNPs with CAD beyond White populations. CONCLUSIONS: Chromosome 9p21 is an important susceptibility locus that confers high cross-race risk for development of CAD.
Authors: Andreas Keller; Angela Graefen; Markus Ball; Mark Matzas; Valesca Boisguerin; Frank Maixner; Petra Leidinger; Christina Backes; Rabab Khairat; Michael Forster; Björn Stade; Andre Franke; Jens Mayer; Jessica Spangler; Stephen McLaughlin; Minita Shah; Clarence Lee; Timothy T Harkins; Alexander Sartori; Andres Moreno-Estrada; Brenna Henn; Martin Sikora; Ornella Semino; Jacques Chiaroni; Siiri Rootsi; Natalie M Myres; Vicente M Cabrera; Peter A Underhill; Carlos D Bustamante; Eduard Egarter Vigl; Marco Samadelli; Giovanna Cipollini; Jan Haas; Hugo Katus; Brian D O'Connor; Marc R J Carlson; Benjamin Meder; Nikolaus Blin; Eckart Meese; Carsten M Pusch; Albert Zink Journal: Nat Commun Date: 2012-02-28 Impact factor: 14.919
Authors: Phillip E Melton; Sue Rutherford; Venkata Saroja Voruganti; Harald H H Göring; Sandra Laston; Karin Haack; Anthony G Comuzzie; Thomas D Dyer; Matthew P Johnson; Jack W Kent; Joanne E Curran; Eric K Moses; John Blangero; Ana Barac; Elisa T Lee; Lyle G Best; Richard R Fabsitz; Richard B Devereux; Peter M Okin; Jonathan N Bella; Uli Broeckel; Barbara V Howard; Jean W MacCluer; Shelley A Cole; Laura Almasy Journal: Hum Mol Genet Date: 2010-07-03 Impact factor: 6.150
Authors: Iván Ferraz-Amaro; Robert Winchester; Peter K Gregersen; Richard J Reynolds; Mary Chester Wasko; Anette Oeser; Cecilia P Chung; C Michael Stein; Jon T Giles; Joan M Bathon Journal: Arthritis Rheumatol Date: 2017-03 Impact factor: 10.995