BACKGROUND: Sympathetic nervous activity, which is regulated by the beta-adrenergic receptor (beta-AR), is an important determinant of the arterial wall-stiffening process. This study examines the genetic influence of beta-AR gene polymorphisms (beta(1)-AR Arg389Gly, beta(2)-AR Arg16Gly, and beta(3)-AR Trp64Arg) on arterial stiffness in black and white young adults. METHODS: The study cohort included 366 black and 891 white adults, aged 19 to 44 years, enrolled in the Bogalusa Heart Study. Aorta-femoral pulse-wave velocity (af-PWV) was measured by echo-Doppler in a subsample (n = 614). RESULTS: Pulse pressure and heart rate were significantly associated with af-PWV in both races, but not with the three polymorphisms. The af-PWV values differed significantly among the beta(1)-AR Arg389Gly genotype groups in whites (P = .007) and in the total sample (P = .005), with those who were homozygous for Gly389 showing higher values than those who were homozygous for Arg389, after adjusting for cardiovascular risk factors. The beta(3)-AR Arg64 allele was associated with higher af-PWV values in blacks (P = .022) and in the total sample (P = .015). The beta(2)-AR Arg16 allele was associated with af-PWV only in blacks (P = .020). In multivariate regression analysis for the total sample, age, pulse pressure, heart rate, beta(1)-AR Arg389Gly, beta(3)-AR trp64Gly, and smoking status were, in descending order, associated with af-PWV. Furthermore, af-PWV values significantly increased with the increasing number of beta(1)-AR Gly389, beta(2)-AR Arg16, and beta(3)-AR Arg64 alleles (P for trend = .0003). CONCLUSIONS: These results indicate that the beta-AR gene polymorphisms influence arterial stiffness in black and white young adults in an additive manner.
BACKGROUND: Sympathetic nervous activity, which is regulated by the beta-adrenergic receptor (beta-AR), is an important determinant of the arterial wall-stiffening process. This study examines the genetic influence of beta-AR gene polymorphisms (beta(1)-ARArg389Gly, beta(2)-ARArg16Gly, and beta(3)-ARTrp64Arg) on arterial stiffness in black and white young adults. METHODS: The study cohort included 366 black and 891 white adults, aged 19 to 44 years, enrolled in the Bogalusa Heart Study. Aorta-femoral pulse-wave velocity (af-PWV) was measured by echo-Doppler in a subsample (n = 614). RESULTS: Pulse pressure and heart rate were significantly associated with af-PWV in both races, but not with the three polymorphisms. The af-PWV values differed significantly among the beta(1)-ARArg389Gly genotype groups in whites (P = .007) and in the total sample (P = .005), with those who were homozygous for Gly389 showing higher values than those who were homozygous for Arg389, after adjusting for cardiovascular risk factors. The beta(3)-ARArg64 allele was associated with higher af-PWV values in blacks (P = .022) and in the total sample (P = .015). The beta(2)-ARArg16 allele was associated with af-PWV only in blacks (P = .020). In multivariate regression analysis for the total sample, age, pulse pressure, heart rate, beta(1)-ARArg389Gly, beta(3)-AR trp64Gly, and smoking status were, in descending order, associated with af-PWV. Furthermore, af-PWV values significantly increased with the increasing number of beta(1)-ARGly389, beta(2)-ARArg16, and beta(3)-ARArg64 alleles (P for trend = .0003). CONCLUSIONS: These results indicate that the beta-AR gene polymorphisms influence arterial stiffness in black and white young adults in an additive manner.
Authors: Gary F Mitchell; Germaine C Verwoert; Kirill V Tarasov; Aaron Isaacs; Albert V Smith; Ernst R Rietzschel; Toshiko Tanaka; Yongmei Liu; Afshin Parsa; Samer S Najjar; Kevin M O'Shaughnessy; Sigurdur Sigurdsson; Marc L De Buyzere; Martin G Larson; Mark P S Sie; Jeanette S Andrews; Wendy S Post; Francesco U S Mattace-Raso; Carmel M McEniery; Gudny Eiriksdottir; Patrick Segers; Ramachandran S Vasan; Marie Josee E van Rijn; Timothy D Howard; Patrick F McArdle; Abbas Dehghan; Elizabeth S Jewell; Stephen J Newhouse; Sofie Bekaert; Naomi M Hamburg; Anne B Newman; Albert Hofman; Angelo Scuteri; Dirk De Bacquer; Mohammad Arfan Ikram; Bruce M Psaty; Christian Fuchsberger; Matthias Olden; Louise V Wain; Paul Elliott; Nicholas L Smith; Janine F Felix; Jeanette Erdmann; Joseph A Vita; Kim Sutton-Tyrrell; Eric J G Sijbrands; Serena Sanna; Lenore J Launer; Tim De Meyer; Andrew D Johnson; Anna F C Schut; David M Herrington; Fernando Rivadeneira; Manuela Uda; Ian B Wilkinson; Thor Aspelund; Thierry C Gillebert; Luc Van Bortel; Emelia J Benjamin; Ben A Oostra; Jingzhong Ding; Quince Gibson; André G Uitterlinden; Gonçalo R Abecasis; John R Cockcroft; Vilmundur Gudnason; Guy G De Backer; Luigi Ferrucci; Tamara B Harris; Alan R Shuldiner; Cornelia M van Duijn; Daniel Levy; Edward G Lakatta; Jacqueline C M Witteman Journal: Circ Cardiovasc Genet Date: 2011-11-08
Authors: Christina L Wassel; David R Jacobs; Daniel A Duprez; David A Bluemke; Christopher T Sibley; Michael H Criqui; Carmen A Peralta Journal: J Am Soc Hypertens Date: 2011-09-03
Authors: Kirill V Tarasov; Serena Sanna; Angelo Scuteri; James B Strait; Marco Orrù; Afshin Parsa; Ping-I Lin; Andrea Maschio; Sandra Lai; Maria Grazia Piras; Marco Masala; Toshiko Tanaka; Wendy Post; Jeffrey R O'Connell; David Schlessinger; Antonio Cao; Ramaiah Nagaraja; Braxton D Mitchell; Gonçalo R Abecasis; Alan R Shuldiner; Manuela Uda; Edward G Lakatta; Samer S Najjar Journal: Circ Cardiovasc Genet Date: 2009-02-18
Authors: Mihail Zilbermint; Amadou Gaye; Annabel Berthon; Fady Hannah-Shmouni; Fabio R Faucz; Maya B Lodish; Adam R Davis; Gary H Gibbons; Constantine A Stratakis Journal: J Am Heart Assoc Date: 2019-07-03 Impact factor: 5.501