Literature DB >> 27493903

Molecular Mechanisms of Arterial Stiffening.

Marina Cecelja1, Phil Chowienczyk1.   

Abstract

Stiffening of large arteries is a hallmark of vascular aging and one of the most important determinants of the age-related increase in blood pressure and cardiovascular disease events. Despite a substantial genetic component, the molecular mechanisms underlying phenotypic variability in arterial stiffness remain unknown. Previous genetic studies have identified several genetic variants that are associated with measures of arterial stiffness. Here, we review the relevant advances in the identification of pathways underlying arterial stiffness from genomic studies.

Entities:  

Keywords:  Arterial calcification; Arterial stiffening; Cardiovascular disease; Genomic studies; Vascular aging

Year:  2016        PMID： 27493903      PMCID： PMC4949363          DOI： 10.1159/000446399

Source DB:  PubMed          Journal:  Pulse (Basel)        ISSN： 2235-8668


  49 in total

1.  Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.

Authors:  Steven Rosenberg; Michael R Elashoff; Philip Beineke; Susan E Daniels; James A Wingrove; Whittemore G Tingley; Philip T Sager; Amy J Sehnert; May Yau; William E Kraus; L Kristin Newby; Robert S Schwartz; Szilard Voros; Stephen G Ellis; Naeem Tahirkheli; Ron Waksman; John McPherson; Alexandra Lansky; Mary E Winn; Nicholas J Schork; Eric J Topol
Journal:  Ann Intern Med       Date:  2010-10-05       Impact factor: 25.391

Review 2.  Vascular calcification: pathobiology of a multifaceted disease.

Authors:  Linda L Demer; Yin Tintut
Journal:  Circulation       Date:  2008-06-03       Impact factor: 29.690

3.  Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance.

Authors:  D J Brull; L J Murray; C A Boreham; S H Ralston; H E Montgomery; A M Gallagher; F E McGuigan; G Davey Smith; M Savage; S E Humphries; I S Young
Journal:  Hypertension       Date:  2001-09       Impact factor: 10.190

4.  Heritability of carotid artery structure and function: the Strong Heart Family Study.

Authors:  Kari E North; Jean W MacCluer; Richard B Devereux; Barbara V Howard; Thomas K Welty; Lyle G Best; Elisa T Lee; Richard R Fabsitz; Mary J Roman
Journal:  Arterioscler Thromb Vasc Biol       Date:  2002-10-01       Impact factor: 8.311

5.  Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals.

Authors:  Carmel M McEniery; Kevin M O'Shaughnessy; Patrick Harnett; Asif Arshad; Sharon Wallace; Kaisa Maki-Petaja; Barry McDonnell; Mike J Ashby; John Brown; John R Cockcroft; Ian B Wilkinson
Journal:  Arterioscler Thromb Vasc Biol       Date:  2006-05-18       Impact factor: 8.311

6.  Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease.

Authors:  Tanya L Medley; Timothy J Cole; Christoph D Gatzka; William Y S Wang; Anthony M Dart; Bronwyn A Kingwell
Journal:  Circulation       Date:  2002-02-19       Impact factor: 29.690

7.  Association of Cross-Sectional and Longitudinal Change in Arterial Stiffness With Gene Expression in the Twins UK Cohort.

Authors:  Marina Cecelja; Benyu Jiang; Massimo Mangino; Tim D Spector; Phil J Chowienczyk
Journal:  Hypertension       Date:  2015-11-16       Impact factor: 10.190

8.  Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.

Authors:  Renate Schnabel; Martin G Larson; Josée Dupuis; Kathryn L Lunetta; Izabella Lipinska; James B Meigs; Xiaoyan Yin; Jian Rong; Joseph A Vita; Christopher Newton-Cheh; Daniel Levy; John F Keaney; Ramachandran S Vasan; Gary F Mitchell; Emelia J Benjamin
Journal:  Hypertension       Date:  2008-04-21       Impact factor: 10.190

9.  Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the Bogalusa Heart Study.

Authors:  Wei Chen; Sathanur R Srinivasan; Eric Boerwinkle; Gerald S Berenson
Journal:  Am J Hypertens       Date:  2007-12       Impact factor: 2.689

10.  A meta-analysis of gene expression signatures of blood pressure and hypertension.

Authors:  Tianxiao Huan; Tõnu Esko; Marjolein J Peters; Luke C Pilling; Katharina Schramm; Claudia Schurmann; Brian H Chen; Chunyu Liu; Roby Joehanes; Andrew D Johnson; Chen Yao; Sai-Xia Ying; Paul Courchesne; Lili Milani; Nalini Raghavachari; Richard Wang; Poching Liu; Eva Reinmaa; Abbas Dehghan; Albert Hofman; André G Uitterlinden; Dena G Hernandez; Stefania Bandinelli; Andrew Singleton; David Melzer; Andres Metspalu; Maren Carstensen; Harald Grallert; Christian Herder; Thomas Meitinger; Annette Peters; Michael Roden; Melanie Waldenberger; Marcus Dörr; Stephan B Felix; Tanja Zeller; Ramachandran Vasan; Christopher J O'Donnell; Peter J Munson; Xia Yang; Holger Prokisch; Uwe Völker; Joyce B J van Meurs; Luigi Ferrucci; Daniel Levy
Journal:  PLoS Genet       Date:  2015-03-18       Impact factor: 5.917
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  7 in total

1.  Brazilian Position Statement on Resistant Hypertension - 2020.

Authors:  Juan Carlos Yugar-Toledo; Heitor Moreno Júnior; Miguel Gus; Guido Bernardo Aranha Rosito; Luiz César Nazário Scala; Elizabeth Silaid Muxfeldt; Alexandre Alessi; Andrea Araújo Brandão; Osni Moreira Filho; Audes Diógenes de Magalhães Feitosa; Oswaldo Passarelli Júnior; Dilma do Socorro Moraes de Souza; Celso Amodeo; Weimar Kunz Sebba Barroso; Marco Antônio Mota Gomes; Annelise Machado Gomes de Paiva; Eduardo Costa Duarte Barbosa; Roberto Dischinger Miranda; José Fernando Vilela-Martin; Wilson Nadruz Júnior; Cibele Isaac Saad Rodrigues; Luciano Ferreira Drager; Luiz Aparecido Bortolotto; Fernanda Marciano Consolim-Colombo; Márcio Gonçalves de Sousa; Flávio Antonio de Oliveira Borelli; Sérgio Emanuel Kaiser; Gil Fernando Salles; Maria de Fátima de Azevedo; Lucélia Batista Neves Cunha Magalhães; Rui Manoel Dos Santos Póvoa; Marcus Vinícius Bolívar Malachias; Armando da Rocha Nogueira; Paulo César Brandão Veiga Jardim; Thiago de Souza Veiga Jardim
Journal:  Arq Bras Cardiol       Date:  2020 May-Jun       Impact factor: 2.000

2.  A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD.

Authors:  Surya P Bhatt; Mark T Dransfield; John R Cockcroft; Jie Wang-Jairaj; Dawn A Midwinter; David B Rubin; Catherine A Scott-Wilson; Courtney Crim
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2017-01-19

3.  Xuezhikang reduced arterial stiffness in patients with essential hypertension: a preliminary study.

Authors:  J Zheng; T Xiao; P Ye; D Miao; H Wu
Journal:  Braz J Med Biol Res       Date:  2017-08-31       Impact factor: 2.590

Review 4.  Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism.

Authors:  Tess De Bruyne; Bieke Steenput; Lynn Roth; Guido R Y De Meyer; Claudia Nunes Dos Santos; Kateřina Valentová; Maija Dambrova; Nina Hermans
Journal:  Nutrients       Date:  2019-03-08       Impact factor: 5.717

5.  Hemodynamic Characterization of Primary Hypertension in Children and Adolescents.

Authors:  Ye Li; Haotian Gu; Manish D Sinha; Phil Chowienczyk
Journal:  J Am Heart Assoc       Date:  2020-06-06       Impact factor: 5.501

6.  Evaluation of aortic 18F-NaF tracer uptake using PET/CT as a predictor of aortic calcification in postmenopausal women: A longitudinal study.

Authors:  Marina Cecelja; Amelia Moore; Ignac Fogelman; Michelle L Frost; Glen M Blake; Phil Chowienczyk
Journal:  JRSM Cardiovasc Dis       Date:  2019-05-08

7.  High-Intensity Statin Therapy Is "Too Much," Thus Not Indicated for Very Elderly Patients.

Authors:  Ok Sang Lee; Jinlong Zhang; Sun-Hoi Jung; Hyang-Sook Kim; Myung-Koo Lee; Hae-Young Lee
Journal:  Pulse (Basel)       Date:  2018-04-12
  7 in total

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