Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

Literature DB >> 18046958

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

Abstract

Inosine monophosphate (IMP) dehydrogenase (IMPDH) is a significant enzyme in the purine nucleotide biosynthetic pathway. IMPDH is viewed as an important biological target in the quest for drugs in the antiviral therapeutic area. This review article is focused on the chemistry and biology of IMPDH inhibitors and the use of IMPDH inhibition data as a probe in antiviral drug discovery. Examples of both inosine 5' monophosphate and NAD+ site-directed inhibitors are presented. Correlation of antiviral activities with IMPDH inhibition is discussed.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 18046958 DOI： 10.1177/095632020701800501

Source DB: PubMed Journal: Antivir Chem Chemother ISSN： 0956-3202

Keyword Cloud
Cited

18 in total

Review 1. IMP dehydrogenase: structure, mechanism, and inhibition.

Authors: Lizbeth Hedstrom
Journal: Chem Rev Date: 2009-07 Impact factor: 60.622

2. Base-functionalized carbocyclic nucleosides: design, synthesis, and mechanism of antiviral activity.

Authors: Vasu Nair; Fan Zhang; Xiaohui Ma; Eric Bonsu
Journal: Nucleosides Nucleotides Nucleic Acids Date: 2009-05 Impact factor: 1.381

3. Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.

Authors: Jong Hyun Cho; Steven J Coats; Raymond F Schinazi
Journal: Tetrahedron Lett Date: 2015-06-03 Impact factor: 2.415

Review 4. Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation.

Authors: Chad K Park; Nancy C Horton
Journal: Biophys Rev Date: 2019-11-16

5. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.

Authors: Magdalena Makowska-Grzyska; Youngchang Kim; Ruiying Wu; Rosemarie Wilton; Deviprasad R Gollapalli; Ximi K Wang; Rongguang Zhang; Robert Jedrzejczak; Jamey C Mack; Natalia Maltseva; Rory Mulligan; T Andrew Binkowski; Piotr Gornicki; Misty L Kuhn; Wayne F Anderson; Lizbeth Hedstrom; Andrzej Joachimiak
Journal: Biochemistry Date: 2012-07-25 Impact factor: 3.162

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

Review 1. IMP dehydrogenase: structure, mechanism, and inhibition.

2. Base-functionalized carbocyclic nucleosides: design, synthesis, and mechanism of antiviral activity.

3. Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.

Review 4. Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation.

5. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.

6. A heterocyclic molecule with significant activity against dengue virus.

7. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Review 8. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes.

9. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.

10. Carbocyclic analogues of inosine-5'-monophosphate: synthesis and biological activity.