Literature DB >> 26028788

Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.

Jong Hyun Cho1, Steven J Coats2, Raymond F Schinazi1.   

Abstract

New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and anti-HCV agents. Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide 15f exhibited modest selective anti-HIV-1 activity (EC50 = 24 µM).

Entities:  

Keywords:  antiviral; carbocyclic ribonucleoside; five-membered nucleobases

Year:  2015        PMID： 26028788      PMCID： PMC4446795          DOI： 10.1016/j.tetlet.2015.01.051

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  45 in total

1.  A new synthetic methodology for tiazofurin.

Authors:  K S Ramasamy; J Y Lau
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2001 Apr-Jul       Impact factor: 1.381

2.  Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Authors:  Lieven J Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung K Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

Review 3.  AMP-activated protein kinase--an archetypal protein kinase cascade?

Authors:  D G Hardie; R W MacKintosh
Journal:  Bioessays       Date:  1992-10       Impact factor: 4.345

4.  Biosynthesis of the purines. XVI. The synthesis of adenosine 5'-phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase.

Authors:  J G FLAKS; M J ERWIN; J M BUCHANAN
Journal:  J Biol Chem       Date:  1957-09       Impact factor: 5.157

5.  Click chemistry under non-classical reaction conditions.

Authors:  C Oliver Kappe; Erik Van der Eycken
Journal:  Chem Soc Rev       Date:  2009-07-27       Impact factor: 54.564

6.  Mitsunobu and related reactions: advances and applications.

Authors:  K C Kumara Swamy; N N Bhuvan Kumar; E Balaraman; K V P Pavan Kumar
Journal:  Chem Rev       Date:  2009-06       Impact factor: 60.622

Review 7.  Applications of orthogonal "click" chemistries in the synthesis of functional soft materials.

Authors:  Rhiannon K Iha; Karen L Wooley; Andreas M Nyström; Daniel J Burke; Matthew J Kade; Craig J Hawker
Journal:  Chem Rev       Date:  2009-11       Impact factor: 60.622

8.  Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.

Authors:  Jong Hyun Cho; Franck Amblard; Steven J Coats; Raymond F Schinazi
Journal:  J Org Chem       Date:  2012-12-26       Impact factor: 4.354

9.  5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase.

Authors:  Ramandeep Rattan; Shailendra Giri; Avtar K Singh; Inderjit Singh
Journal:  J Biol Chem       Date:  2005-09-21       Impact factor: 5.157

10.  The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

Authors:  Lee G D Fryer; Asha Parbu-Patel; David Carling
Journal:  J Biol Chem       Date:  2002-05-06       Impact factor: 5.157
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  2 in total

1.  Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.

Authors:  Keivan Zandi; Franck Amblard; Sarah Amichai; Leda Bassit; Sijia Tao; Yong Jiang; Longhu Zhou; Olivia Ollinger Russell; Seema Mengshetti; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

2.  Characterization of a Citrulline 4-Hydroxylase from Nonribosomal Peptide GE81112 Biosynthesis and Engineering of Its Substrate Specificity for the Chemoenzymatic Synthesis of Enduracididine.

Authors:  Christian R Zwick; Max B Sosa; Hans Renata
Journal:  Angew Chem Int Ed Engl       Date:  2019-11-11       Impact factor: 15.336
  2 in total

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