Literature DB >> 18042144

Chromatin-modifying proteins in cancer.

Cathrine K Fog1, Klaus T Jensen, Anders H Lund.   

Abstract

Chromatin-modifying proteins mold the genome into areas that are accessible for transcriptional activity and areas that are transcriptionally silent. This epigenetic gene regulation allows for different transcriptional programs to be conducted in different cell types at different timepoints-despite the fact that all cells in the organism contain the same genetic information. A large amount of data gathered over the last decades has demonstrated that deregulation of chromatin-modifying proteins is etiologically involved in the development and progression of cancer. Here we discuss how epigenetic alterations influence cancer development and review known cancer-associated alterations in chromatin-modifying proteins.

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Year:  2007        PMID： 18042144     DOI： 10.1111/j.1600-0463.2007.apm_776.xml.x

Source DB:  PubMed          Journal:  APMIS        ISSN： 0903-4641            Impact factor:   3.205


  15 in total

1.  Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

Authors:  Feng Liu; Xin Chen; Abdellah Allali-Hassani; Amy M Quinn; Gregory A Wasney; Aiping Dong; Dalia Barsyte; Ivona Kozieradzki; Guillermo Senisterra; Irene Chau; Alena Siarheyeva; Dmitri B Kireev; Ajit Jadhav; J Martin Herold; Stephen V Frye; Cheryl H Arrowsmith; Peter J Brown; Anton Simeonov; Masoud Vedadi; Jian Jin
Journal:  J Med Chem       Date:  2009-12-24       Impact factor: 7.446

Review 2.  Structure and function of long noncoding RNAs in epigenetic regulation.

Authors:  Tim R Mercer; John S Mattick
Journal:  Nat Struct Mol Biol       Date:  2013-03       Impact factor: 15.369

Review 3.  Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules.

Authors:  Pilar Blancafort; Jian Jin; Stephen Frye
Journal:  Mol Pharmacol       Date:  2012-11-13       Impact factor: 4.436

4.  Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

Authors:  Feng Liu; Xin Chen; Abdellah Allali-Hassani; Amy M Quinn; Tim J Wigle; Gregory A Wasney; Aiping Dong; Guillermo Senisterra; Irene Chau; Alena Siarheyeva; Jacqueline L Norris; Dmitri B Kireev; Ajit Jadhav; J Martin Herold; William P Janzen; Cheryl H Arrowsmith; Stephen V Frye; Peter J Brown; Anton Simeonov; Masoud Vedadi; Jian Jin
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

5.  Identification of protoberberine alkaloids as novel histone methyltransferase G9a inhibitors by structure-based virtual screening.

Authors:  Jie Chen; Xiao Lin; Kyoung Jin Park; Kang Ro Lee; Hyun-Ju Park
Journal:  J Comput Aided Mol Des       Date:  2018-08-31       Impact factor: 3.686

6.  Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

Authors:  Feng Liu; Dalia Barsyte-Lovejoy; Abdellah Allali-Hassani; Yunlong He; J Martin Herold; Xin Chen; Christopher M Yates; Stephen V Frye; Peter J Brown; Jing Huang; Masoud Vedadi; Cheryl H Arrowsmith; Jian Jin
Journal:  J Med Chem       Date:  2011-08-05       Impact factor: 7.446

Review 7.  Epigenetic aberrations during oncogenesis.

Authors:  Maria Hatziapostolou; Dimitrios Iliopoulos
Journal:  Cell Mol Life Sci       Date:  2011-01-20       Impact factor: 9.261

8.  Epigenetics: Tools and Technologies.

Authors:  William P Janzen; Tim J Wigle; Jian Jin; Stephen V Frye
Journal:  Drug Discov Today Technol       Date:  2010

9.  An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

Authors:  Kyle D Konze; Anqi Ma; Fengling Li; Dalia Barsyte-Lovejoy; Trevor Parton; Christopher J Macnevin; Feng Liu; Cen Gao; Xi-Ping Huang; Ekaterina Kuznetsova; Marie Rougie; Alice Jiang; Samantha G Pattenden; Jacqueline L Norris; Lindsey I James; Bryan L Roth; Peter J Brown; Stephen V Frye; Cheryl H Arrowsmith; Klaus M Hahn; Gang Greg Wang; Masoud Vedadi; Jian Jin
Journal:  ACS Chem Biol       Date:  2013-04-24       Impact factor: 5.100

10.  Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients.

Authors:  Massimo Mascolo; Maria Luisa Vecchione; Gennaro Ilardi; Massimiliano Scalvenzi; Guido Molea; Maria Di Benedetto; Loredana Nugnes; Maria Siano; Gaetano De Rosa; Stefania Staibano
Journal:  BMC Cancer       Date:  2010-02-24       Impact factor: 4.430
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