| Literature DB >> 18032041 |
Oleg V Yarishkin1, Hyung Won Ryu, Jae-Yong Park, Min Suk Yang, Seong-Geun Hong, Ki Hun Park.
Abstract
Chalcone derivatives 1-17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9-17, in which the sulfonyloxy group is placed on the A-ring. The 3'-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51+/-0.05 microM) was the most potent K+ channel blocker.Entities:
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Year: 2007 PMID： 18032041 DOI： 10.1016/j.bmcl.2007.10.114
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823