| Literature DB >> 18024124 |
Harutaka Katano1, Yuko Sato, Satomi Hoshino, Natsuo Tachikawa, Shinichi Oka, Yasuyuki Morishita, Takaomi Ishida, Toshiki Watanabe, William N Rom, Shigeo Mori, Tetsutaro Sata, Michael D Weiden, Yoshihiko Hoshino.
Abstract
Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding transcription factor activated by multiple cytokines and interferons. High expression of STAT3 has also been implicated in cancer and lymphoma. Here, we show a case of B cell lymphoma in which a defective human immunodeficiency virus 1 (HIV-1) integrated upstream of the first STAT3 coding exon. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of an acquired immunodeficiency syndrome (AIDS) patient with Kaposi's sarcoma. The provirus had a 5' long terminal repeat (LTR) deletion, but the 3' LTR had stronger promoter activity than the STAT3 promoter in reporter assays. Immunohistochemistry showed increased expression of STAT3 in the nuclei of lymphoma cells. Transfection of STAT3 resulted in transient cell proliferation in primary B cells in vitro. Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case.Entities:
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Year: 2007 PMID： 18024124 PMCID： PMC2200298 DOI： 10.1016/j.micinf.2007.09.008
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700