| Literature DB >> 24968937 |
F Maldarelli1, X Wu2, L Su2, F R Simonetti3, W Shao2, S Hill1, J Spindler1, A L Ferris1, J W Mellors4, M F Kearney1, J M Coffin5, S H Hughes6.
Abstract
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.Entities:
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Year: 2014 PMID： 24968937 PMCID： PMC4262401 DOI： 10.1126/science.1254194
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728