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Literature DB >> 18007397

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.

Javier Figueroa¹, Esther Caballero, Pilar Puebla, Fernando Tomé, Manuel Medarde.

Abstract

The reactivity of 6-(nitrophenyl or trimethoxyphenyl)-4-tert-butyldimethyl- siloxy-1,2,3,6-tetrahydropyridine derivatives with hydrazines under acid conditions is described. The structure of the products isolated - hydrazones, pyrazolines or pyridazinones - depended on the conditions used. In addition, a systematic study of the reaction outcomes was carried out by introducing variations on the substituents of the tetrahydropyridine ring.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 18007397 PMCID： PMC6148654 DOI： 10.3390/11110929

Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411

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References

7 in total

1. Stereocontrolled total synthesis of (-)-eudistomin C.

Authors: Tohru Yamashita; Nobutaka Kawai; Hidetoshi Tokuyama; Tohru Fukuyama
Journal: J Am Chem Soc Date: 2005-11-02 Impact factor: 15.419

2. Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein.

Authors: Fedele Manna; Franco Chimenti; Rossella Fioravanti; Adriana Bolasco; Daniela Secci; Paola Chimenti; Cristiano Ferlini; Giovanni Scambia
Journal: Bioorg Med Chem Lett Date: 2005-10-15 Impact factor: 2.823

3. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives.

Authors: Rihui Cao; Wenlie Peng; Hongsheng Chen; Xuerui Hou; Huaji Guan; Qi Chen; Yan Ma; Anlong Xu
Journal: Eur J Med Chem Date: 2005-01-13 Impact factor: 6.514

4. Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

Authors: Christopher D Cox; Maricel Torrent; Michael J Breslin; Brenda J Mariano; David B Whitman; Paul J Coleman; Carolyn A Buser; Eileen S Walsh; Kelly Hamilton; Michael D Schaber; Robert B Lobell; Weikang Tao; Vicki J South; Nancy E Kohl; Youwei Yan; Lawrence C Kuo; Thomayant Prueksaritanont; Donald E Slaughter; Chunze Li; Elizabeth Mahan; Bing Lu; George D Hartman
Journal: Bioorg Med Chem Lett Date: 2006-04-05 Impact factor: 2.823

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.

1. Stereocontrolled total synthesis of (-)-eudistomin C.

2. Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein.

3. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives.

4. Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

5. Syntheses of functionalized 1,4-disubstituted gamma-carbolines.

6. Synthesis of heterocycles from alkyl 3-(dimethylamino)propenoates and related enaminones.

7. Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues.