| Literature DB >> 16248638 |
Tohru Yamashita1, Nobutaka Kawai, Hidetoshi Tokuyama, Tohru Fukuyama.
Abstract
A stereocontrolled total synthesis of (-)-eudistomin C was accomplished in 18-step sequence with an overall yield of 7.7%. The synthesis features the diastereoselective Pictet-Spengler reaction of a tryptamine derivative and the Garner aldehyde catalyzed by Bronsted acids, and the unprecedented construction of the unusual oxathiazepine ring by intramolecular alkylation.Entities:
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Year: 2005 PMID： 16248638 DOI： 10.1021/ja055832h
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419