Literature DB >> 17979801

Recent advances towards new anti-infective agents that inhibit cell surface protein anchoring in Staphylococcus aureus and other gram-positive pathogens.

N Suree1, M E Jung, R T Clubb.   

Abstract

Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.

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Year:  2007        PMID： 17979801     DOI： 10.2174/138955707782110097

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  26 in total

1.  Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.

Authors:  Paul R Race; Matthew L Bentley; Jeff A Melvin; Allister Crow; Richard K Hughes; Wendy D Smith; Richard B Sessions; Michael A Kehoe; Dewey G McCafferty; Mark J Banfield
Journal:  J Biol Chem       Date:  2009-01-06       Impact factor: 5.157

2.  The Sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture.

Authors:  Ethan M Weiner; Scott Robson; Melanie Marohn; Robert T Clubb
Journal:  J Biol Chem       Date:  2010-05-19       Impact factor: 5.157

Review 3.  Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.

Authors:  Kathleen W Clancy; Jeffrey A Melvin; Dewey G McCafferty
Journal:  Biopolymers       Date:  2010       Impact factor: 2.505

Review 4.  Targeting virulence not viability in the search for future antibacterials.

Authors:  Begoña Heras; Martin J Scanlon; Jennifer L Martin
Journal:  Br J Clin Pharmacol       Date:  2015-02       Impact factor: 4.335

5.  Solution structure of the sortase required for efficient production of infectious Bacillus anthracis spores.

Authors:  Scott A Robson; Alex W Jacobitz; Martin L Phillips; Robert T Clubb
Journal:  Biochemistry       Date:  2012-09-27       Impact factor: 3.162

6.  Effect of SrtA on Interspecies Adherence of Oral Bacteria.

Authors:  Ying Song; Jin-Zhi He; Ren-Ke Wang; Jing-Zhi Ma; Ling Zou
Journal:  Curr Med Sci       Date:  2018-03-15

7.  Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.

Authors:  Nuttee Suree; Sung Wook Yi; William Thieu; Melanie Marohn; Robert Damoiseaux; Albert Chan; Michael E Jung; Robert T Clubb
Journal:  Bioorg Med Chem       Date:  2009-09-06       Impact factor: 3.641

8.  Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESS.

Authors:  Albert H Chan; Sung Wook Yi; Austen L Terwilliger; Anthony W Maresso; Michael E Jung; Robert T Clubb
Journal:  J Biol Chem       Date:  2015-08-31       Impact factor: 5.157

9.  Discovery of Staphylococcus aureus sortase A inhibitors using virtual screening and the relaxed complex scheme.

Authors:  Albert H Chan; Jeff Wereszczynski; Brendan R Amer; Sung Wook Yi; Michael E Jung; J Andrew McCammon; Robert T Clubb
Journal:  Chem Biol Drug Des       Date:  2013-10       Impact factor: 2.817

Review 10.  Productive steps toward an antimicrobial targeting virulence.

Authors:  Amy K Barczak; Deborah T Hung
Journal:  Curr Opin Microbiol       Date:  2009-07-22       Impact factor: 7.934
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