Literature DB >> 24552512

Targeting virulence not viability in the search for future antibacterials.

Begoña Heras1, Martin J Scanlon, Jennifer L Martin.   

Abstract

New antibacterials need new approaches to overcome the problem of rapid antibiotic resistance. Here we review the development of potential new antibacterial drugs that do not kill bacteria or inhibit their growth, but combat disease instead by targeting bacterial virulence.
© 2014 The British Pharmacological Society.

Keywords:  antibacterial; antivirulence; bacterial infection; pilicide; quorum sensing

Mesh：

Substances：

Year:  2015        PMID： 24552512      PMCID： PMC4309627          DOI： 10.1111/bcp.12356

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  77 in total

Review 1.  Mechanisms and synthetic modulators of AHL-dependent gene regulation.

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2.  Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation.

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Journal:  Cell       Date:  2006-11-17       Impact factor: 41.582

Review 3.  Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules.

Authors:  Herman O Sintim; Jacqueline A I Smith; Jingxin Wang; Shizuka Nakayama; Lei Yan
Journal:  Future Med Chem       Date:  2010-06       Impact factor: 3.808

4.  Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.

Authors:  Deborah T Hung; Elizabeth A Shakhnovich; Emily Pierson; John J Mekalanos
Journal:  Science       Date:  2005-10-13       Impact factor: 47.728

5.  Identification of a protein required for disulfide bond formation in vivo.

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Journal:  Cell       Date:  1991-11-01       Impact factor: 41.582

Review 6.  Glycodendrimers as anti-adhesion drugs against type 1 fimbriated E. coli uropathogenic infections.

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Journal:  Mini Rev Med Chem       Date:  2007-12       Impact factor: 3.862

7.  Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.

Authors:  Lynette Cegelski; Jerome S Pinkner; Neal D Hammer; Corinne K Cusumano; Chia S Hung; Erik Chorell; Veronica Aberg; Jennifer N Walker; Patrick C Seed; Fredrik Almqvist; Matthew R Chapman; Scott J Hultgren
Journal:  Nat Chem Biol       Date:  2009-10-25       Impact factor: 15.040

8.  Mutants in disulfide bond formation that disrupt flagellar assembly in Escherichia coli.

Authors:  F E Dailey; H C Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-01       Impact factor: 11.205

9.  Two periplasmic disulfide oxidoreductases, DsbA and SrgA, target outer membrane protein SpiA, a component of the Salmonella pathogenicity island 2 type III secretion system.

Authors:  Tsuyoshi Miki; Nobuhiko Okada; Hirofumi Danbara
Journal:  J Biol Chem       Date:  2004-05-28       Impact factor: 5.157

Review 10.  Bacterial toxins: friends or foes?

Authors:  C K Schmitt; K C Meysick; A D O'Brien
Journal:  Emerg Infect Dis       Date:  1999 Mar-Apr       Impact factor: 6.883
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  55 in total

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Authors:  Jennifer H Martin; Albert Ferro
Journal:  Br J Clin Pharmacol       Date:  2015-02       Impact factor: 4.335

2.  Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site.

Authors:  Lakshmanane Premkumar; Fabian Kurth; Wilko Duprez; Morten K Grøftehauge; Gordon J King; Maria A Halili; Begoña Heras; Jennifer L Martin
Journal:  J Biol Chem       Date:  2014-05-23       Impact factor: 5.157

3.  Signaling by a Conserved Quorum Sensing Pathway Contributes to Growth Ex Vivo and Oropharyngeal Colonization of Human Pathogen Group A Streptococcus.

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Journal:  Infect Immun       Date:  2018-04-23       Impact factor: 3.441

4.  Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.

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Journal:  J Med Chem       Date:  2017-10-03       Impact factor: 7.446

5.  Solonamides, a Group of Cyclodepsipeptides, Influence Motility in the Native Producer Photobacterium galatheae S2753.

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6.  Peptide-Based Inhibitors of Fimbrial Biogenesis in Porphyromonas gingivalis.

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Journal:  Infect Immun       Date:  2019-02-21       Impact factor: 3.441

7.  Prediction of Burkholderia pseudomallei DsbA substrates identifies potential virulence factors and vaccine targets.

Authors:  Ben Vezina; Guillaume A Petit; Jennifer L Martin; Maria A Halili
Journal:  PLoS One       Date:  2020-11-20       Impact factor: 3.240

8.  Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics.

Authors:  Tucker Maxson; Douglas A Mitchell
Journal:  Tetrahedron       Date:  2015-10-09       Impact factor: 2.457

9.  Antivirulence activity of auranofin against vancomycin-resistant enterococci: in vitro and in vivo studies.

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10.  Surfaceome and Exoproteome Dynamics in Dual-Species Pseudomonas aeruginosa and Staphylococcus aureus Biofilms.

Authors:  Inés Reigada; Paola San-Martin-Galindo; Shella Gilbert-Girard; Jacopo Chiaro; Vincenzo Cerullo; Kirsi Savijoki; Tuula A Nyman; Adyary Fallarero; Ilkka Miettinen
Journal:  Front Microbiol       Date:  2021-06-25       Impact factor: 5.640
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