Literature DB >> 17979227

Use of NMR metabolomics to analyze the targets of D-cycloserine in mycobacteria: role of D-alanine racemase.

Steven Halouska1, Ofelia Chacon, Robert J Fenton, Denise K Zinniel, Raul G Barletta, Robert Powers.   

Abstract

D-Cycloserine (DCS) is only used with multidrug-resistant strains of tuberculosis because of serious side effects. DCS is known to inhibit cell wall biosynthesis, but the in vivo lethal target is still unknown. We have applied NMR-based metabolomics combined with principal component analysis to monitor the in vivo effect of DCS on Mycobacterium smegmatis. Our analysis suggests DCS functions by inhibiting multiple protein targets.

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Year:  2007        PMID： 17979227      PMCID： PMC2566856          DOI： 10.1021/pr0704332

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  45 in total

1.  Treatment and implications of multidrug-resistant tuberculosis for the 21st century.

Authors:  M D Iseman
Journal:  Chemotherapy       Date:  1999       Impact factor: 2.544

Review 2.  NMR spectral quantitation by principal component analysis.

Authors:  R Stoyanova; T R Brown
Journal:  NMR Biomed       Date:  2001-06       Impact factor: 4.044

3.  Common structural elements in the architecture of the cofactor-binding domains in unrelated families of pyridoxal phosphate-dependent enzymes.

Authors:  K A Denessiouk; A I Denesyuk; J V Lehtonen; T Korpela; M S Johnson
Journal:  Proteins       Date:  1999-05-01

4.  Negative impact of noise on the principal component analysis of NMR data.

Authors:  Steven Halouska; Robert Powers
Journal:  J Magn Reson       Date:  2005-09-27       Impact factor: 2.229

5.  Mycobacterium smegmatis D-Alanine Racemase Mutants Are Not Dependent on D-Alanine for Growth.

Authors:  Ofelia Chacon; Zhengyu Feng; N Beth Harris; Nancy E Cáceres; L Garry Adams; Raúl G Barletta
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

6.  N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatment.

Authors:  Sebabrata Mahapatra; Hataichanok Scherman; Patrick J Brennan; Dean C Crick
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

7.  Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W.

Authors:  M P Lambert; F C Neuhaus
Journal:  J Bacteriol       Date:  1972-06       Impact factor: 3.490

8.  The 92-min region of the Escherichia coli chromosome: location and cloning of the ubiA and alr genes.

Authors:  P E Lilley; N P Stamford; S G Vasudevan; N E Dixon
Journal:  Gene       Date:  1993-07-15       Impact factor: 3.688

9.  HMDB: the Human Metabolome Database.

Authors:  David S Wishart; Dan Tzur; Craig Knox; Roman Eisner; An Chi Guo; Nelson Young; Dean Cheng; Kevin Jewell; David Arndt; Summit Sawhney; Chris Fung; Lisa Nikolai; Mike Lewis; Marie-Aude Coutouly; Ian Forsythe; Peter Tang; Savita Shrivastava; Kevin Jeroncic; Paul Stothard; Godwin Amegbey; David Block; David D Hau; James Wagner; Jessica Miniaci; Melisa Clements; Mulu Gebremedhin; Natalie Guo; Ying Zhang; Gavin E Duggan; Glen D Macinnis; Alim M Weljie; Reza Dowlatabadi; Fiona Bamforth; Derrick Clive; Russ Greiner; Liang Li; Tom Marrie; Brian D Sykes; Hans J Vogel; Lori Querengesser
Journal:  Nucleic Acids Res       Date:  2007-01       Impact factor: 16.971

10.  Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks.

Authors:  O Fiehn
Journal:  Comp Funct Genomics       Date:  2001
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  31 in total

1.  Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens.

Authors:  Timo Birkenstock; Manuel Liebeke; Volker Winstel; Bernhard Krismer; Cordula Gekeler; Maria J Niemiec; Hans Bisswanger; Michael Lalk; Andreas Peschel
Journal:  J Biol Chem       Date:  2011-12-05       Impact factor: 5.157

2.  Thiadiazolidinones: a new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus.

Authors:  Mihai Ciustea; Sara Mootien; Adriana E Rosato; Oriana Perez; Pier Cirillo; Kacheong R Yeung; Michel Ledizet; Michael H Cynamon; Paul A Aristoff; Raymond A Koski; Paul A Kaplan; Karen G Anthony
Journal:  Biochem Pharmacol       Date:  2011-11-29       Impact factor: 5.858

3.  Predicting the in vivo mechanism of action for drug leads using NMR metabolomics.

Authors:  Steven Halouska; Robert J Fenton; Raúl G Barletta; Robert Powers
Journal:  ACS Chem Biol       Date:  2011-12-01       Impact factor: 5.100

4.  Advances in Nuclear Magnetic Resonance for Drug Discovery.

Authors:  Robert Powers
Journal:  Expert Opin Drug Discov       Date:  2009-10-01       Impact factor: 6.098

5.  Unraveling the concentration-dependent metabolic response of Pseudomonas sp. HF-1 to nicotine stress by ¹H NMR-based metabolomics.

Authors:  Yangfang Ye; Xin Wang; Limin Zhang; Zhenmei Lu; Xiaojun Yan
Journal:  Ecotoxicology       Date:  2012-03-22       Impact factor: 2.823

Review 6.  Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.

Authors:  Brett C Covington; John A McLean; Brian O Bachmann
Journal:  Nat Prod Rep       Date:  2017-01-04       Impact factor: 13.423

7.  Sample preparation of Mycobacterium tuberculosis extracts for nuclear magnetic resonance metabolomic studies.

Authors:  Denise K Zinniel; Robert J Fenton; Steven Halouska; Robert Powers; Raul G Barletta
Journal:  J Vis Exp       Date:  2012-09-03       Impact factor: 1.355

8.  Using NMR metabolomics to investigate tricarboxylic acid cycle-dependent signal transduction in Staphylococcus epidermidis.

Authors:  Marat R Sadykov; Bo Zhang; Steven Halouska; Jennifer L Nelson; Lauren W Kreimer; Yefei Zhu; Robert Powers; Greg A Somerville
Journal:  J Biol Chem       Date:  2010-09-22       Impact factor: 5.157

9.  Analysis of metabolomic PCA data using tree diagrams.

Authors:  Mark T Werth; Steven Halouska; Matthew D Shortridge; Bo Zhang; Robert Powers
Journal:  Anal Biochem       Date:  2009-12-21       Impact factor: 3.365

10.  Characterization and preliminary mutation analysis of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4.

Authors:  Zhangwei Xue; Yi Hu; Shujing Xu; Kouhei Ohnishi; Yanhe Ma; Jiansong Ju; Baohua Zhao
Journal:  Extremophiles       Date:  2013-05-24       Impact factor: 2.395
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