BACKGROUND: Peripherally inserted central catheters (PICC) in children and adolescents are being used with increasing frequency. We sought to determine the incidence and characterize risk factors of deep vein thrombosis associated with peripherally inserted central catheters in a pediatric population. METHODS: We conducted a prospective study involving consecutive patients referred to the radiology department of a tertiary care university-affiliated hospital for insertion of a peripherally inserted central catheter. We included patients aged 18 years or less who weighed more than 2.5 kg and had a peripherally inserted central catheter successfully inserted in his or her arm between June 2004 and November 2005. The primary outcome was the occurrence of partial or complete deep vein thrombosis evaluated by clinical examination, ultrasonography and venous angiography. RESULTS: A total of 214 patients (101 girls, 113 boys) were included in the study. Partial or complete deep vein thrombosis occurred in 20 patients, for an incidence of 93.5 per 1000 patients and 3.85 per 1000 catheter-days. Only 1 of the cases was symptomatic. In the univariable analyses, the only variable significantly associated with deep vein thrombosis was the presence of factor II mutation G20210A (odds ratio 7.08, 95% confidence interval 1.11-45.15, p = 0.04), a genetic mutation that increases the risk of a blood clot and that was present in 5 (2.3%) of the 214 patients. INTERPRETATION: The incidence of deep vein thrombosis related to peripherally inserted central catheters in our study was lower than the incidence related to centrally inserted venous catheters described in the pediatric literature (11%-50%).
BACKGROUND: Peripherally inserted central catheters (PICC) in children and adolescents are being used with increasing frequency. We sought to determine the incidence and characterize risk factors of deep vein thrombosis associated with peripherally inserted central catheters in a pediatric population. METHODS: We conducted a prospective study involving consecutive patients referred to the radiology department of a tertiary care university-affiliated hospital for insertion of a peripherally inserted central catheter. We included patients aged 18 years or less who weighed more than 2.5 kg and had a peripherally inserted central catheter successfully inserted in his or her arm between June 2004 and November 2005. The primary outcome was the occurrence of partial or complete deep vein thrombosis evaluated by clinical examination, ultrasonography and venous angiography. RESULTS: A total of 214 patients (101 girls, 113 boys) were included in the study. Partial or complete deep vein thrombosis occurred in 20 patients, for an incidence of 93.5 per 1000 patients and 3.85 per 1000 catheter-days. Only 1 of the cases was symptomatic. In the univariable analyses, the only variable significantly associated with deep vein thrombosis was the presence of factor II mutation G20210A (odds ratio 7.08, 95% confidence interval 1.11-45.15, p = 0.04), a genetic mutation that increases the risk of a blood clot and that was present in 5 (2.3%) of the 214 patients. INTERPRETATION: The incidence of deep vein thrombosis related to peripherally inserted central catheters in our study was lower than the incidence related to centrally inserted venous catheters described in the pediatric literature (11%-50%).
Authors: A W Allen; J L Megargell; D B Brown; F C Lynch; H Singh; Y Singh; P N Waybill Journal: J Vasc Interv Radiol Date: 2000 Nov-Dec Impact factor: 3.464
Authors: Christoph Male; Peter Chait; Jeffrey S Ginsberg; Kim Hanna; Maureen Andrew; Jacqueline Halton; Ron Anderson; Patricia McCusker; John Wu; Thomas Abshire; Irene Cherrick; Donald Mahoney; Lesley Mitchell Journal: Thromb Haemost Date: 2002-04 Impact factor: 5.249
Authors: J Merrer; B De Jonghe; F Golliot; J Y Lefrant; B Raffy; E Barre; J P Rigaud; D Casciani; B Misset; C Bosquet; H Outin; C Brun-Buisson; G Nitenberg Journal: JAMA Date: 2001-08-08 Impact factor: 56.272
Authors: Claire Infante-Rivard; Georges-Etienne Rivard; Wagner V Yotov; Emmanuelle Génin; Marguerite Guiguet; Clarice Weinberg; Robert Gauthier; Juan Carlos Feoli-Fonseca Journal: N Engl J Med Date: 2002-07-04 Impact factor: 91.245
Authors: Edward Vincent S Faustino; Philip C Spinella; Simon Li; Matthew G Pinto; Petronella Stoltz; Joana Tala; Mary Elizabeth Card; Veronika Northrup; Kenneth E Baker; T Rob Goodman; Lei Chen; Cicero T Silva Journal: J Pediatr Date: 2012-08-09 Impact factor: 4.406
Authors: Ralph Gnannt; Nicolas Waespe; Michael Temple; Afsaneh Amirabadi; Kuan Liu; Leonardo R Brandão; Bairbre L Connolly Journal: Pediatr Radiol Date: 2018-02-27