Literature DB >> 17971743

Cytotoxicity of two triterpenoids from Nigella glandulifera.

Ze Tian1, Yu-Ming Liu, Si-Bao Chen, Jun-Shan Yang, Pei-Gen Xiao, Liao Wang, Erxi Wu.   

Abstract

During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma.

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Year:  2006        PMID： 17971743      PMCID： PMC6148551          DOI： 10.3390/11090693

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


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