Literature DB >> 12871157

Plant-derived triterpenoids as potential antineoplastic agents.

W N Setzer1, M C Setzer.   

Abstract

Man has relied on plants as a source of medicinal agents for centuries. Today, with the specter of antibiotic resistance, emerging infectious diseases, and cancers, phytochemicals continue to provide new structural leads for the chemotherapeutic industry. A number of triterpenoids have shown promise as antineoplastic agents. Members of the cycloartane, lupane, ursane, oleanane, friedelane (especially quinone methides), dammarane, cucurbitacin, and limonoid triterpenoids, have demonstrated anti-proliferative activity on various cancer cell lines. This review covers the recent developments regarding antineoplastic/cytotoxic triterpenoids, excluding saponins, from higher plants.

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Year:  2003        PMID： 12871157     DOI： 10.2174/1389557033487854

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  33 in total

1.  Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.

Authors:  Nisha R Parikh; Animesh Mandal; Deepak Bhatia; Kodappully Sivaraman Siveen; Gautam Sethi; Anupam Bishayee
Journal:  Phytochem Rev       Date:  2014-12       Impact factor: 5.374

2.  Olea europaea leaf extract alters microRNA expression in human glioblastoma cells.

Authors:  Berrin Tunca; Gulcin Tezcan; Gulsah Cecener; Unal Egeli; Secil Ak; Hulusi Malyer; Gulendam Tumen; Ayhan Bilir
Journal:  J Cancer Res Clin Oncol       Date:  2012-06-22       Impact factor: 4.553

3.  Activation of apoptosis by derivatives of betulinic acid in human tumor cells in vitro.

Authors:  A G Pokrovskii; A B Shintyapina; N V Pronkina; V S Kozhevnikov; O A Plyasunova; E E Shul'ts; G A Tolstikov
Journal:  Dokl Biochem Biophys       Date:  2006 Mar-Apr       Impact factor: 0.788

4.  Bioactive principles in the bark of Pilidiostigma tropicum.

Authors:  William N Setzer; Glenn F Rozmus; Mary C Setzer; Jennifer M Schmidt; Bernhard Vogler; Sabine Reeb; Betsy R Jackes; Anthony K Irvine
Journal:  J Mol Model       Date:  2006-04-07       Impact factor: 1.810

5.  Olea europaea leaf extract improves the treatment response of GBM stem cells by modulating miRNA expression.

Authors:  Gulcin Tezcan; Berrin Tunca; Ahmet Bekar; Ferah Budak; Saliha Sahin; Gulsah Cecener; Unal Egeli; Mevlut Ozgur Taskapılıoglu; Hasan Kocaeli; Sahsine Tolunay; Hulusi Malyer; Cevdet Demir; Gulendam Tumen
Journal:  Am J Cancer Res       Date:  2014-09-06       Impact factor: 6.166

6.  Capilliposide C derived from Lysimachia capillipes Hemsl inhibits growth of human prostate cancer PC3 cells by targeting caspase and MAPK pathways.

Authors:  Ruyi Li; Leilei Zhang; Lijing Zhang; Dan Chen; Jingkui Tian; Li Cao; Lin Zhang
Journal:  Int Urol Nephrol       Date:  2014-02-20       Impact factor: 2.370

7.  A theoretical investigation of cytotoxic activity of celastroid triterpenoids.

Authors:  William N Setzer
Journal:  J Mol Model       Date:  2008-12-02       Impact factor: 1.810

8.  Cytotoxicity of two triterpenoids from Nigella glandulifera.

Authors:  Ze Tian; Yu-Ming Liu; Si-Bao Chen; Jun-Shan Yang; Pei-Gen Xiao; Liao Wang; Erxi Wu
Journal:  Molecules       Date:  2006-09-13       Impact factor: 4.411

9.  The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.

Authors:  G Harish Kumar; R Vidya Priyadarsini; G Vinothini; P Vidjaya Letchoumy; S Nagini
Journal:  Invest New Drugs       Date:  2009-05-21       Impact factor: 3.850

10.  Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling.

Authors:  Gui'e Xie; Xinpei Yu; Huichao Liang; Jingsong Chen; Xuewei Tang; Shaoqing Wu; Can Liao
Journal:  Oncol Lett       Date:  2016-03-16       Impact factor: 2.967
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