Literature DB >> 17971740

Synthesis and antiviral bioactivities of alpha-aminophosphonates containing alkoxyethyl moieties.

Yingshu Xu1, Kai Yan, Baoan Song, Gangfang Xu, Song Yang, Wei Xue, Deyu Hu, Ping Lu, Guiping Ouyang, Linhong Jin, Zhuo Chen.   

Abstract

A simple, efficient, and general method has been developed for the synthesis of various alpha-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of the representative compound 4l was determined. The new alpha-aminophosphonate derivatives were found to possess moderate to good antiviral activity.

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Year:  2006        PMID： 17971740      PMCID： PMC6148563          DOI： 10.3390/11090666

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  3 in total

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Journal:  Bioorg Med Chem Lett       Date:  2006-01-06       Impact factor: 2.823
  3 in total
  9 in total

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2.  Harnessing Thin-Film Continuous-Flow Assembly Lines.

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Authors:  Maheshwara Reddy Nadiveedhi; Poojith Nuthalapati; Mohan Gundluru; Mohan Reddy Yanamula; Saritha Venkatareddy Kallimakula; Visweswara Rao Pasupuleti; Vijaya Kumar Reddy Avula; Swetha Vallela; Grigory Vasilievich Zyryanov; Satheesh Krishna Balam; Suresh Reddy Cirandur
Journal:  ACS Omega       Date:  2021-01-21

8.  Theoretical exploration on structures, bonding aspects and molecular docking of α-aminophosphonate ligated copper complexes against SARS-CoV-2 proteases.

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9.  Rapid synthesis and antiviral activity of (quinazolin-4-ylamino)methyl-phosphonates through microwave irradiation.

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  9 in total

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