| Literature DB >> 10658571 |
S Du1, H Faiger, V Belakhov, T Baasov.
Abstract
The design and two synthetic pathways to aminophosphonate 4 which mimics the ionic and steric properties of putative oxocarbenium intermediate 3 in the Kdo8P synthase-catalyzed reaction are reported. It was found that 4 is a slow-binding, most potent inhibitor of the enzyme yet tested, with a Ki value of 0.4 microM.Entities:
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Year: 1999 PMID： 10658571 DOI： 10.1016/s0968-0896(99)00233-3
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641