Literature DB >> 17971729

Synthesis and anticancer activities of novel 1,4-disubstituted phthalazines.

Juan Li1, Yan-Fang Zhao, Xiao-Ye Yuan, Jing-Xiong Xu, Ping Gong.   

Abstract

A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method.

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Year:  2006        PMID： 17971729      PMCID： PMC6148564          DOI： 10.3390/11070574

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  4 in total

1.  o-Acetobenzoic acid, its preparation and lactonization; a novel application of the Doebner synthesis.

Authors:  H L YALE
Journal:  J Am Chem Soc       Date:  1947-06       Impact factor: 15.419

2.  Phthalazine PDE IV inhibitors: conformational study of some 6-methoxy-1,4-disubstituted derivatives.

Authors:  Thomas Haack; Raimondo Fattori; Mauro Napoletano; Franco Pellacini; Giovanni Fronza; Giuseppina Raffaini; Fabio Ganazzoli
Journal:  Bioorg Med Chem       Date:  2005-07-15       Impact factor: 3.641

3.  Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.

Authors:  M Napoletano; G Norcini; F Pellacini; F Marchini; G Morazzoni; P Ferlenga; L Pradella
Journal:  Bioorg Med Chem Lett       Date:  2001-01-08       Impact factor: 2.823

4.  Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines.

Authors:  Ramaiya Sivakumar; Sundararaj Kishore Gnanasam; Somasundaram Ramachandran; Joseph Thomas Leonard
Journal:  Eur J Med Chem       Date:  2002-10       Impact factor: 6.514
  4 in total
  9 in total

1.  Magnetically recoverable Fe3O4 nanocatalyst for the synthesis of biodynamically significant 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives and its DFT study.

Authors:  Mohd Danish Ansari; Hozeyfa Sagir; Vijay B Yadav; Neetu Yadav; Ankit Verma; Sonam Shakya; Manjit Singh; I R Siddiqui
Journal:  Mol Divers       Date:  2022-10-07       Impact factor: 3.364

2.  An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation.

Authors:  Fatma S Elsharabasy; Sobhi M Gomha; Thoraya A Farghaly; Heba S A Elzahabi
Journal:  Molecules       Date:  2017-02-18       Impact factor: 4.411

3.  Combination of active components enhances the efficacy of Prunella in prevention and treatment of lung cancer.

Authors:  Liang Feng; Xiao-Bin Jia; Jun Jiang; Mao-Mao Zhu; Yan Chen; Xiao-Bin Tan; Feng Shi
Journal:  Molecules       Date:  2010-11-04       Impact factor: 4.411

4.  Metal-Free Air Oxidation in a Convenient Cascade Approach for the Access to Isoquinoline-1,3,4(2H)-triones.

Authors:  Antonia Di Mola; Consiglia Tedesco; Antonio Massa
Journal:  Molecules       Date:  2019-06-10       Impact factor: 4.411

5.  Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity.

Authors:  Zbigniew Malinowski; Emilia Fornal; Agata Sumara; Renata Kontek; Karol Bukowski; Beata Pasternak; Dariusz Sroczyński; Joachim Kusz; Magdalena Małecka; Monika Nowak
Journal:  Beilstein J Org Chem       Date:  2021-02-25       Impact factor: 2.883

6.  Cascade annulation reaction (CAR): highly diastereoselective synthesis of pyranopyrazole scaffolds.

Authors:  Manickam Bakthadoss; Manickam Surendar
Journal:  RSC Adv       Date:  2020-05-19       Impact factor: 4.036

7.  A new efficient domino approach for the synthesis of pyrazolyl-phthalazine-diones. Antiradical activity of novel phenolic products.

Authors:  Dušica Simijonović; Zorica D Petrović; Vesna M Milovanović; Vladimir P Petrović; Goran A Bogdanović
Journal:  RSC Adv       Date:  2018-05-04       Impact factor: 4.036

8.  Preparation, characterization, and use of novel Cu@Fe3O4 MNPs in the synthesis of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones and 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions.

Authors:  Lilin Jiang; Zumrat Druzhinin
Journal:  RSC Adv       Date:  2019-05-14       Impact factor: 4.036

9.  Synthesis of Novel Phthalazinedione-Based Derivatives with Promising Cytotoxic, Anti-bacterial, and Molecular Docking Studies as VEGFR2 Inhibitors.

Authors:  Samir M El Rayes; Gaber El Enany; Ibrahim A I Ali; Wessam Ibrahim; Mohamed S Nafie
Journal:  ACS Omega       Date:  2022-06-27
  9 in total

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