Literature DB >> 17971721

Synthesis of some thienopyrimidine derivatives.

Fatma E M El-Baih1, Hanan A S Al-Blowy, Hassan M Al-Hazimi.   

Abstract

Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo-pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2-amino-3-cyano-4,5-disubstituted thiophenes via reactions with different reagents.

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Year:  2006        PMID： 17971721      PMCID： PMC6148655          DOI： 10.3390/11070498

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  10 in total

1.  Synthesis and antiinflammatory activity of certain thienopyrimidine derivatives.

Authors:  M M el-Kerdawy; M Y Yousif; A A el-Emam; M A Moustafa; M A el-Sherbeny
Journal:  Boll Chim Farm       Date:  1996-05

2.  Synthesis of 3-substituted thieno [2, 3-d] pyrimidin-4(3H)-one-2-mercaptoacetic acids and their ethyl esters for pharmacological screening.

Authors:  M B Devani; C J Shishoo; U S Pathak; S H Parikh; G F Shah; A C Padhya
Journal:  J Pharm Sci       Date:  1976-05       Impact factor: 3.534

3.  Thienopyrimidine derivatives prevent cartilage destruction in articular disease.

Authors:  A Santagati; B Gentile
Journal:  Farmaco       Date:  2001-12

4.  Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells.

Authors:  Lee D Jennings; Scott L Kincaid; Yanong D Wang; Girija Krishnamurthy; Carl F Beyer; John P McGinnis; Miriam Miranda; Carolyn M Discafani; Sridhar K Rabindran
Journal:  Bioorg Med Chem Lett       Date:  2005-11-01       Impact factor: 2.823

5.  Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).

Authors:  M D Meyer; R J Altenbach; F Z Basha; W A Carroll; S Condon; S W Elmore; J F Kerwin; K B Sippy; K Tietje; M D Wendt; A A Hancock; M E Brune; S A Buckner; I Drizin
Journal:  J Med Chem       Date:  2000-04-20       Impact factor: 7.446

6.  High affinity and selectivity of [[(arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives for the 5-HT(1A) receptor. Synthesis and structure-affinity relationships.

Authors:  M Modica; M Santagati; F Russo; C Selvaggini; A Cagnotto; T Mennini
Journal:  Eur J Med Chem       Date:  2000 Jul-Aug       Impact factor: 6.514

7.  Synthesis of new [1,3,4]thiadiazolo[3,2-a]thieno[2,3-d]pyrimidinone derivatives with antiinflammatory activity.

Authors:  M Modica; M Santagati; A Santagati; V Cutuli; N Mangano; A Caruso
Journal:  Pharmazie       Date:  2000-07       Impact factor: 1.267

8.  Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents.

Authors:  Ravindra V Chambhare; Barsu G Khadse; Anil S Bobde; Rajesh H Bahekar
Journal:  Eur J Med Chem       Date:  2003-01       Impact factor: 6.514

9.  Studies on cardiotonic agents. VII. Potent cardiotonic agent KF15232 with myofibrillar Ca2+ sensitizing effect.

Authors:  Y Nomoto; H Takai; T Ohno; K Kubo
Journal:  Chem Pharm Bull (Tokyo)       Date:  1991-04       Impact factor: 1.645

10.  Synthesis and pharmacological evaluation of thieno[2,3-d]pyrimidin-2,4-dione and 5H-pyrimido [5,4-b]indol-2,4-dione derivatives.

Authors:  N A Santagati; A Caruso; V M Cutuli; F Caccamo
Journal:  Farmaco       Date:  1995-10
  10 in total
  5 in total

1.  Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents.

Authors:  Marwa A Aziz; Rabah A T Serya; Deena S Lasheen; Amal Kamal Abdel-Aziz; Ahmed Esmat; Ahmed M Mansour; Abdel Nasser B Singab; Khaled A M Abouzid
Journal:  Sci Rep       Date:  2016-04-15       Impact factor: 4.379

2.  Pyridine-based heterocycles. Synthesis of new pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and related heterocycles.

Authors:  Hussein El-Kashef; Abdel-Rahman Farghaly; Ahmed Al-Hazmi; Thierry Terme; Patrice Vanelle
Journal:  Molecules       Date:  2010-04-12       Impact factor: 4.411

3.  Synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines.

Authors:  Khulud M Al-Taisan; Hassan M A Al-Hazimi; Shar S Al-Shihry
Journal:  Molecules       Date:  2010-06-01       Impact factor: 4.411

4.  Synthesis of novel Schiff bases using 2-Amino-5-(3-fluoro-4-methoxyphenyl)thiophene-3-carbonitrile and 1,3-Disubstituted pyrazole-4-carboxaldehydes derivatives and their antimicrobial activity.

Authors:  Divyaraj Puthran; Boja Poojary; Nikil Purushotham; Nandam Harikrishna; Soukhyarani Gopal Nayak; Vinuta Kamat
Journal:  Heliyon       Date:  2019-08-26

5.  Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines.

Authors:  Marwa Sharaky; Marwa Kamel; Marwa A Aziz; Mervat Omran; Monira M Rageh; Khaled A M Abouzid; Samia A Shouman
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  5 in total

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