Literature DB >> 10944776

Synthesis of new [1,3,4]thiadiazolo[3,2-a]thieno[2,3-d]pyrimidinone derivatives with antiinflammatory activity.

M Modica1, M Santagati, A Santagati, V Cutuli, N Mangano, A Caruso.   

Abstract

New thiadiazolothienopyrimidinones were synthesized in continuation of efforts to prepare thienopyrimidine derivatives with analgesic and antiinflammatory activities. In this study, the effect of various substituents in the thiophene ring on the pharmacological activity of the compounds was investigated.

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Year:  2000        PMID： 10944776     DOI： 10.1002/chin.200042143

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  5 in total

1.  Anti-inflammatory and immunomodulatory effects of RDV-8 [C18H22N2O2S (ethyl 1-butyl-6-methyl-2-phenyl-4-thioxo-1,4-dihydropyrimidine-5-carboxylate)] in a rat model of induced pleurisy and in vitro lymphoproliferation.

Authors:  Marcos Schuch Azambuja; Adroaldo Lunardelli; Robson Henrich Amaral; Fernanda Bordignon Nunes; Eduardo Caberlon; Vinicius Lorini da Costa; Márcio Vinícius Fagundes Donadio; Daniela Nunes Vitor; Alberto da Silva Melo Denizar; Silvio Cunha; Jarbas Rodrigues de Oliveira
Journal:  Inflammopharmacology       Date:  2010-10-28       Impact factor: 4.473

2.  Synthesis of some thienopyrimidine derivatives.

Authors:  Fatma E M El-Baih; Hanan A S Al-Blowy; Hassan M Al-Hazimi
Journal:  Molecules       Date:  2006-07-05       Impact factor: 4.411

3.  Comparative computational studies of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives as potential antinociceptive agents.

Authors:  Janaína V dos Anjos; Rajendra M Srivastava; João H Costa-Silva; Luciana Scotti; Marcus T Scotti; Almir G Wanderley; Elisa Soares Leite; Sebastião J de Melo; Francisco J B Mendonça Junior
Journal:  Molecules       Date:  2012-01-16       Impact factor: 4.411

4.  Synthesis of Some 4,5-Dihydrothieno[3,2-e][1,2,4]Triazolo[4,3-a] Pyrimi-dine-2-Carboxamides as Anti-Inflammatory and Analgesic Agents.

Authors:  Omaima G Shaaban; Ola H Rizk; Aida E Bayad; Ibrahim M El-Ashmawy
Journal:  Open Med Chem J       Date:  2013-11-29

5.  Synthesis and antimicrobial activity of some new thieno[2,3-b]thiophene derivatives.

Authors:  Yahia Nasser Mabkhot; Nabila Abdelshafy Kheder; Ahmad M Farag
Journal:  Molecules       Date:  2013-04-19       Impact factor: 4.411
  5 in total

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