| Literature DB >> 17970699 |
Daniëlle de Jong1, Berry P H Kremer, Marcel G M Olde Rikkert, Marcel M Verbeek.
Abstract
In this comprehensive review, we summarize the current state-of-the-art of neurochemical biomarkers for Alzheimer's disease. Predominantly, these biomarkers comprise cerebrospinal fluid biomarkers directly related to the pathophysiology of this disorder (such as amyloid beta protein, tau protein). We particularly pay attention to the innovations in this area that have been made in technological aspects during the past 5 years (e.g., multiplex analysis of biomarkers, proteomics), to the discovery of novel, potential biomarkers (e.g., amyloid beta oligomers, isoprostanes), and to the extension of this research towards identification of biomarkers in plasma.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17970699 DOI： 10.1515/CCLM.2007.320
Source DB: PubMed Journal: Clin Chem Lab Med ISSN： 1434-6621 Impact factor: 3.694