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Literature DB >> 22445294

Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?

Abstract

The innate immune system is a crucial component of inflammatory reactions, while the central nervous system (CNS) is the most vulnerable site of the body to inflammatory tissue injury. Neuroinflammatory brain pathologies are disorders in which the CNS is threatened by its own immune system. Chemokine receptor CXCR2 and its ligands have been implicated in several neuroinflammatory brain pathologies, as well as in neutrophil recruitment and in the developmental positioning of neural cells. This review focuses on the basics of CXCR2, its regulating role in bone marrow neutrophil recruitment, oligodendrocyte progenitor cell positioning and neural repair mechanisms, as well as its diverse roles in neuroinflammatory brain pathologies.

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Year: 2012 PMID： 22445294 PMCID： PMC3335977 DOI： 10.1016/j.jneuroim.2012.02.016

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

127 in total

1. Cytokine regulation of CC and CXC chemokine expression by human astrocytes.

Authors: J W Oh; L M Schwiebert; E N Benveniste
Journal: J Neurovirol Date: 1999-02 Impact factor: 2.643

2. Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis.

Authors: A R Glabinski; V K Tuohy; R M Ransohoff
Journal: Neuroimmunomodulation Date: 1998 May-Aug Impact factor: 2.492

3. The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation.

Authors: S Robinson; M Tani; R M Strieter; R M Ransohoff; R H Miller
Journal: J Neurosci Date: 1998-12-15 Impact factor: 6.167

4. Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.

Authors: A R Glabinski; M Tani; R M Strieter; V K Tuohy; R M Ransohoff
Journal: Am J Pathol Date: 1997-02 Impact factor: 4.307

Review 5. Chemokine receptor internalization and intracellular trafficking.

Authors: Nicole F Neel; Evemie Schutyser; Jiqing Sai; Guo-Huang Fan; Ann Richmond
Journal: Cytokine Growth Factor Rev Date: 2005-07-05 Impact factor: 7.638

6. Role for CXCR2 and CXCL1 on glia in multiple sclerosis.

Authors: Kakuri M Omari; Gareth John; Richard Lango; Cedric S Raine
Journal: Glia Date: 2006-01-01 Impact factor: 7.452

7. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

Authors: M P Crump; J H Gong; P Loetscher; K Rajarathnam; A Amara; F Arenzana-Seisdedos; J L Virelizier; M Baggiolini; B D Sykes; I Clark-Lewis
Journal: EMBO J Date: 1997-12-01 Impact factor: 11.598

8. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production.

Authors: T Kossmann; P F Stahel; P M Lenzlinger; H Redl; R W Dubs; O Trentz; G Schlag; M C Morganti-Kossmann
Journal: J Cereb Blood Flow Metab Date: 1997-03 Impact factor: 6.200

9. Identification of two rat genes orthologous to the human interleukin-8 receptors.

Authors: C A Dunstan; M N Salafranca; S Adhikari; Y Xia; L Feng; J K Harrison
Journal: J Biol Chem Date: 1996-12-20 Impact factor: 5.157

10. Treatment with anti-granulocyte antibodies inhibits the effector phase of experimental autoimmune encephalomyelitis.

Authors: S R McColl; M A Staykova; A Wozniak; S Fordham; J Bruce; D O Willenborg
Journal: J Immunol Date: 1998-12-01 Impact factor: 5.422

30 in total

Review 1. Pancreatic islet inflammation: an emerging role for chemokines.

Authors: J Jason Collier; Tim E Sparer; Michael D Karlstad; Susan J Burke
Journal: J Mol Endocrinol Date: 2017-04-18 Impact factor: 5.098

Review 2. Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell-cell communication by chemokines.

Authors: Stefka Gyoneva; Richard M Ransohoff
Journal: Trends Pharmacol Sci Date: 2015-05-13 Impact factor: 14.819

3. Early elevated levels of soluble triggering receptor expressed on myeloid cells-1 in subarachnoid hemorrhage patients.

Authors: Xin-Gang Sun; Qian Ma; Gang Jing; Li Wang; Xu-Dong Hao; Gai-Qing Wang
Journal: Neurol Sci Date: 2017-02-22 Impact factor: 3.307

Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?

1. Cytokine regulation of CC and CXC chemokine expression by human astrocytes.

2. Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis.

3. The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation.

4. Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.

Review 5. Chemokine receptor internalization and intracellular trafficking.

6. Role for CXCR2 and CXCL1 on glia in multiple sclerosis.

7. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

8. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production.

9. Identification of two rat genes orthologous to the human interleukin-8 receptors.

10. Treatment with anti-granulocyte antibodies inhibits the effector phase of experimental autoimmune encephalomyelitis.

Review 1. Pancreatic islet inflammation: an emerging role for chemokines.

Review 2. Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell-cell communication by chemokines.

3. Early elevated levels of soluble triggering receptor expressed on myeloid cells-1 in subarachnoid hemorrhage patients.

Review 4. CXCR2: a target for pancreatic cancer treatment?

Review 5. Inflammatory Disequilibrium in Stroke.

6. Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice.

7. CXCL3 Signaling in the Tumor Microenvironment.

Review 8. The immune system and developmental programming of brain and behavior.

9. Lipopolysaccharide Upregulates the Expression of CINC-3 and LIX in Primary NG2 Cells.

10. Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway.