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Literature DB >> 17965742

Evidence against C-type natriuretic peptide as an arterial 'EDHF'.

Abstract

C-type natriuretic peptide (CNP) is found in and released from vascular endothelial cells. Recently, a novel role has been suggested for this peptide, that of an endothelium-derived hyperpolarizing factor or EDHF. Implicit in this proposal is a widespread role for CNP as a key mediator of vascular dilatation. In this issue of the British Journal of Pharmacology, Leuranguer et al. compare the profile of membrane potential changes evoked with this putative EDHF or with endogenous EDHF (activated with ACh) in small carotid arteries. Marked differences between the two profiles lead them to discount a possible role for CNP as an EDHF.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2007 PMID： 17965742 PMCID： PMC2199387 DOI： 10.1038/sj.bjp.0707520

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

13 in total

1. Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery.

Authors: F Plane; C J Garland
Journal: Br J Pharmacol Date: 1996-09 Impact factor: 8.739

2. Endothelium-independent relaxation and hyperpolarization to C-type natriuretic peptide in porcine coronary arteries.

Authors: M Barton; J L Bény; L V d'Uscio; T Wyss; G Noll; T F Lüscher
Journal: J Cardiovasc Pharmacol Date: 1998-03 Impact factor: 3.105

3. Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids.

Authors: Arthur H Weston; Michel Félétou; Paul M Vanhoutte; John R Falck; William B Campbell; Gillian Edwards
Journal: Br J Pharmacol Date: 2005-07 Impact factor: 8.739

4. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.

Authors: Adrian Hobbs; Paul Foster; Craig Prescott; Ramona Scotland; Amrita Ahluwalia
Journal: Circulation Date: 2004-08-30 Impact factor: 29.690

5. Vascular actions of C-type natriuretic peptide in isolated porcine coronary arteries and coronary vascular smooth muscle cells.

Authors: C M Wei; S Hu; V M Miller; J C Burnett
Journal: Biochem Biophys Res Commun Date: 1994-11-30 Impact factor: 3.575

6. Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery.

Authors: G J Crane; C J Garland
Journal: Br J Pharmacol Date: 2004-03-29 Impact factor: 8.739

7. Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor.

Authors: Sharmila D Chauhan; Holger Nilsson; Amrita Ahluwalia; Adrian J Hobbs
Journal: Proc Natl Acad Sci U S A Date: 2003-01-27 Impact factor: 11.205

Review 4. Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids.

Authors: David C Ellinsworth; Scott Earley; Timothy V Murphy; Shaun L Sandow
Journal: Pflugers Arch Date: 2013-06-08 Impact factor: 3.657

4 in total

Evidence against C-type natriuretic peptide as an arterial 'EDHF'.

1. Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery.

2. Endothelium-independent relaxation and hyperpolarization to C-type natriuretic peptide in porcine coronary arteries.

3. Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids.

4. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.

5. Vascular actions of C-type natriuretic peptide in isolated porcine coronary arteries and coronary vascular smooth muscle cells.

6. Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery.

7. Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor.

Review 8. Endothelium-derived hyperpolarizing factor: where are we now?

9. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels.

10. C-type natriuretic peptide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery.

1. Endothelium in pharmacology: 30 years on.

2. Robert F. Furchgott, Nobel laureate (1916-2009)--a personal reflection.

Review 3. Endothelium-derived hyperpolarising factors and associated pathways: a synopsis.

Review 4. Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids.