Literature DB >> 8886397

Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery.

F Plane1, C J Garland.   

Abstract

This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase-independent repolarization to acetylcholine-evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre-contraction. Noradrenaline-induced contractions were reversed by acetylcholine via both NO and NO synthase-independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane-mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.

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Year:  1996        PMID： 8886397      PMCID： PMC1915844          DOI： 10.1111/j.1476-5381.1996.tb15970.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  4 in total

1.  Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels.

Authors:  G R Drummond; T M Cocks
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

2.  Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery.

Authors:  C J Garland; G A McPherson
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

3.  Noradrenaline contracts arteries by activating voltage-dependent calcium channels.

Authors:  M T Nelson; N B Standen; J E Brayden; J F Worley
Journal:  Nature       Date:  1988-11-24       Impact factor: 49.962

4.  Contribution of both nitric oxide and a change in membrane potential to acetylcholine-induced relaxation in the rat small mesenteric artery.

Authors:  G J Waldron; C J Garland
Journal:  Br J Pharmacol       Date:  1994-07       Impact factor: 8.739
  4 in total
  18 in total

1.  Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles.

Authors:  T Dalsgaard; C Kroigaard; M Misfeldt; T Bek; U Simonsen
Journal:  Br J Pharmacol       Date:  2010-07       Impact factor: 8.739

2.  PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

Authors:  Makhala Michell Khammy; Thomas Dalsgaard; Peter Hjørringgaard Larsen; Claus Tornby Christoffersen; Dorte Clausen; Lars Kyhn Rasmussen; Lasse Folkersen; Morten Grunnet; Jan Kehler; Christian Aalkjaer; Jacob Nielsen
Journal:  Br J Pharmacol       Date:  2017-10-15       Impact factor: 8.739

3.  Vasoconstrictor stimulus determines the functional contribution of myoendothelial feedback to mesenteric arterial tone.

Authors:  R Wei; S E Lunn; R Tam; S L Gust; B Classen; P M Kerr; F Plane
Journal:  J Physiol       Date:  2018-03-05       Impact factor: 5.182

4.  Potentiation of cyclic AMP-mediated vasorelaxation by phenylephrine in pulmonary arteries of the rat.

Authors:  R M Priest; D Hucks; J P Ward
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

5.  Motility of the ureter of the spontaneously hypertensive rat.

Authors:  D Rasidovic; S J Bund
Journal:  Ir J Med Sci       Date:  2011-01-12       Impact factor: 1.568

6.  Mechanisms of 17 beta-oestradiol induced vasodilatation in isolated pressurized rat small arteries.

Authors:  L Shaw; M J Taggart; C Austin
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

7.  Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries.

Authors:  C A McIntyre; C H Buckley; G C Jones; T C Sandeep; R C Andrews; A I Elliott; G A Gray; B C Williams; J A McKnight; B R Walker; P W Hadoke
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

8.  Different modulation by Ca2+-activated K+ channel blockers and herbimycin of acetylcholine- and flow-evoked vasodilatation in rat mesenteric small arteries.

Authors:  Michael Thorsgaard; Vanesa Lopez; Niels H Buus; Ulf Simonsen
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

9.  Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery.

Authors:  G J Crane; C J Garland
Journal:  Br J Pharmacol       Date:  2004-03-29       Impact factor: 8.739

10.  Evidence against C-type natriuretic peptide as an arterial 'EDHF'.

Authors:  C J Garland; K A Dora
Journal:  Br J Pharmacol       Date:  2007-10-29       Impact factor: 8.739
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