| Literature DB >> 19608394 |
Amanda M Holland1, Marcel R M van den Brink.
Abstract
The elderly face significant risk for susceptibility to infection and cancer because of declining immune function. Various agents used in the setting of bone marrow transplantation and aging studies represent promising approaches to combating T cell defects in the aging population. Preclinical and clinical studies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be used to alleviate the effects of T cell deficiencies in the elderly.Entities:
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Year: 2009 PMID： 19608394 PMCID： PMC2731988 DOI： 10.1016/j.coi.2009.06.002
Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486