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Literature DB >> 17962016

Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library.

Dianqing Sun¹, Victoria Jones, Elizabeth I Carson, Robin E B Lee, Michael S Scherman, Michael R McNeil, Richard E Lee.

Abstract

A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. High-throughput screening of this library for anti-tuberculosis activity identified several members with a MIC(90) value of 12.5 microg/mL.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2007 PMID： 17962016 PMCID： PMC2140236 DOI： 10.1016/j.bmcl.2007.09.097

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

10 in total

1. A solid-phase approach to analogues of the antibiotic mureidomycin.

Authors: A Bozzoli; W Kazmierski; G Kennedy; A Pasquarello; A Pecunioso
Journal: Bioorg Med Chem Lett Date: 2000-12-18 Impact factor: 2.823

2. Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin.

Authors: C G Boojamra; R C Lemoine; J C Lee; R Léger; K A Stein; N G Vernier; A Magon; O Lomovskaya; P K Martin; S Chamberland; M D Lee; S J Hecker; V J Lee
Journal: J Am Chem Soc Date: 2001-02-07 Impact factor: 15.419

3. Alternative to piperidine in Fmoc solid-phase synthesis.

Authors: John Hachmann; Michal Lebl
Journal: J Comb Chem Date: 2006 Mar-Apr

Review 4. Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis.

Authors: Ken-ichi Kimura; Timothy D H Bugg
Journal: Nat Prod Rep Date: 2003-04 Impact factor: 13.423

5. Synthesis and activity of 5'-uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A.

Authors: Nigel I Howard; Timothy D H Bugg
Journal: Bioorg Med Chem Date: 2003-07-17 Impact factor: 3.641

6. Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. I. Taxonomy, fermentation, isolation and physico-chemical properties.

Authors: M Inukai; F Isono; S Takahashi; R Enokita; Y Sakaida; T Haneishi
Journal: J Antibiot (Tokyo) Date: 1989-05 Impact factor: 2.649

7. Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. III. Biological properties.

Authors: F Isono; T Katayama; M Inukai; T Haneishi
Journal: J Antibiot (Tokyo) Date: 1989-05 Impact factor: 2.649

8. Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.

Authors: Constantine G Boojamra; Rémy C Lemoine; Johanne Blais; Nicole G Vernier; Karin A Stein; Angela Magon; Suzanne Chamberland; Scott J Hecker; Ving J Lee
Journal: Bioorg Med Chem Lett Date: 2003-10-06 Impact factor: 2.823

9. Solid-phase synthesis of a thymidinyl dipeptide urea library.

Authors: Dianqing Sun; Richard E Lee
Journal: J Comb Chem Date: 2007-04-07

10. Selective inhibition of the bacterial translocase reaction in peptidoglycan synthesis by mureidomycins.

Authors: M Inukai; F Isono; A Takatsuki
Journal: Antimicrob Agents Chemother Date: 1993-05 Impact factor: 5.191