| Literature DB >> 17934475 |
Lianrong Wang1, Shi Chen, Tiegang Xu, Koli Taghizadeh, John S Wishnok, Xiufen Zhou, Delin You, Zixin Deng, Peter C Dedon.
Abstract
Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.Entities:
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Year: 2007 PMID： 17934475 DOI： 10.1038/nchembio.2007.39
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040