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Literature DB >> 17914459

Histone chaperones regulate histone exchange during transcription.

Hye-Jin Kim¹, Ja-Hwan Seol, Jeung-Whan Han, Hong-Duk Youn, Eun-Jung Cho.

Abstract

Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. The results showed that the exchange of H3/H4 normally occurs during transcription by the histone chaperones. Both Asf1 and HIR are important for histone deposition but have a different effect on histone exchange. While Asf1 mediated incorporation of external H3/H4 and renewal of pre-existing histones, HIR opposed it. The balance of two opposing activities might be an important mechanism for determining current chromatin states.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17914459 PMCID： PMC2063486 DOI： 10.1038/sj.emboj.7601870

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

44 in total

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33 in total

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