AIM: To compare the prevalence of H pylori infection, peptic ulcer, cytomegalovirus (CMV) infection and Candida esophagitis in human immunodeficiency virus (HIV)-positive and HIV-negative patients, and evaluate the impact of CD4 lymphocyte on H pylori and opportunistic infections. METHODS: A total of 151 patients (122 HIV-positive and 29 HIV-negative) with gastrointestinal symptoms were examined by upper endoscopy and biopsy. Samples were assessed to determine the prevalence of H pylori infection, CMV, candida esophagitis and histologic chronic gastritis. RESULTS: The prevalence of H pylori was less common in HIV-positive patients (22.1%) than in HIV-negative controls (44.8%; P < 0.05), and the prevalence of H pylori displayed a direct correlation with CD4 count stratification in HIV-positive patients. In comparison with HIV-negative group, HIV-positive patients had a lower incidence of peptic ulcer (20.7% vs 4.1%; P < 0.01), but a higher prevalence of chronic atrophy gastritis (6.9% vs 24.6%; P < 0.05)ìCandida esophagitis and CMV infection. Unlike HIV-negative group, H pylori infection had a close relationship to chronic active gastritis (P < 0.05). In HIV-positive patients, chronic active gastritis was not significantly different between those with H pylori infection and those without. CONCLUSION: The lower prevalence of H pylori infection and peptic ulcer in HIV-positive patients with gastrointestinal symptoms suggests a different mechanism of peptic ulcerogenesis and a different role of H pylori infection in chronic active gastritis and peptic ulcer. The pathogen of chronic active gastritis in HIV-positive patients may be different from the general population that is closely related to H pylori infection.
AIM: To compare the prevalence of H pylori infection, peptic ulcer, cytomegalovirus (CMV) infection and Candida esophagitis in human immunodeficiency virus (HIV)-positive and HIV-negative patients, and evaluate the impact of CD4 lymphocyte on H pylori and opportunistic infections. METHODS: A total of 151 patients (122 HIV-positive and 29 HIV-negative) with gastrointestinal symptoms were examined by upper endoscopy and biopsy. Samples were assessed to determine the prevalence of H pylori infection, CMV, candida esophagitis and histologic chronic gastritis. RESULTS: The prevalence of H pylori was less common in HIV-positivepatients (22.1%) than in HIV-negative controls (44.8%; P < 0.05), and the prevalence of H pylori displayed a direct correlation with CD4 count stratification in HIV-positivepatients. In comparison with HIV-negative group, HIV-positivepatients had a lower incidence of peptic ulcer (20.7% vs 4.1%; P < 0.01), but a higher prevalence of chronic atrophy gastritis (6.9% vs 24.6%; P < 0.05)ìCandida esophagitis and CMV infection. Unlike HIV-negative group, H pylori infection had a close relationship to chronic active gastritis (P < 0.05). In HIV-positivepatients, chronic active gastritis was not significantly different between those with H pylori infection and those without. CONCLUSION: The lower prevalence of H pylori infection and peptic ulcer in HIV-positivepatients with gastrointestinal symptoms suggests a different mechanism of peptic ulcerogenesis and a different role of H pylori infection in chronic active gastritis and peptic ulcer. The pathogen of chronic active gastritis in HIV-positivepatients may be different from the general population that is closely related to H pylori infection.
Authors: P Fabris; A Pilotto; L Bozzola; G Tositti; G Soffiati; V Manfrin; F de Lalla Journal: Aliment Pharmacol Ther Date: 2002-04 Impact factor: 8.171
Authors: W L Peterson; D Y Graham; B Marshall; M J Blaser; R M Genta; P D Klein; C W Stratton; J Drnec; P Prokocimer; N Siepman Journal: Am J Gastroenterol Date: 1993-11 Impact factor: 10.864
Authors: George Z Panos; Elias Xirouchakis; Vasilis Tzias; Gerasimos Charatsis; Ioannis A Bliziotis; Vasilis Doulgeroglou; Nikos Margetis; Matthew E Falagas Journal: AIDS Res Hum Retroviruses Date: 2007-05 Impact factor: 2.205
Authors: A G Cacciarelli; B J Marano; N M Gualtieri; A R Zuretti; R A Torres; A A Starpoli; J G Robilotti Journal: Am J Gastroenterol Date: 1996-09 Impact factor: 10.864
Authors: L C N Brito; A P Ribeiro Sobrinho; R P Teles; S S Socransky; A D Haffajee; L Q Vieira; F R F Teles Journal: Oral Dis Date: 2012-02-15 Impact factor: 3.511
Authors: Andréa B C Fialho; Manuel B Braga-Neto; Eder J C Guerra; André M N Fialho; Karine C Fernandes; Juliana L M Sun; Christianne F V Takeda; Cícero I S Silva; Dulciene M M Queiroz; Lucia L B C Braga Journal: BMC Gastroenterol Date: 2011-02-19 Impact factor: 3.067
Authors: E Christina Persson; Meredith S Shiels; Sanford M Dawsey; Kishor Bhatia; Lesley A Anderson; Eric A Engels Journal: Gastroenterology Date: 2012-07-14 Impact factor: 22.682
Authors: Joe Geraghty; Alexander Thumbs; Anstead Kankwatira; Tim Andrews; Andrew Moore; Rose Malamba; Neema Mtunthama; Kai Hellberg; Lughano Kalongolera; Paul O'Toole; Andrea Varro; D Mark Pritchard; Melita Gordon Journal: PLoS One Date: 2015-08-05 Impact factor: 3.240