BACKGROUND: The relationship between serum parameters of gastric function and Helicobacter pylori infection in human immunodeficiency virus (HIV)-positive patients is almost unknown. AIMS: To investigate in HIV-infected patients: (i) the relationship between serum gastrin and serum pepsinogens over the progressive phases of HIV-related disease; (ii) the impact of H. pylori infection on gastrin and pepsinogen serum levels and its relation to antral histology; (iii) the prevalence of parietal cell autoantibodies. METHODS: Fifty-nine HIV-positive patients were studied by upper endoscopy plus gastric antral biopsy. Serum samples were tested for gastrin, pepsinogen A, pepsinogen C and parietal cell autoantibodies. RESULTS: In patients without overt acquired immunodeficiency syndrome (AIDS), or with a CD4+ count of > 100 x 10(6) cells/L, mean serum levels of gastrin and pepsinogen C were higher than in subjects with AIDS or with a CD4+ count of < 100 x 10(6) cells/L (P < 0.01). Only one patient was found to be positive for parietal cell autoantibodies. H. pylori infection was associated with increased values of gastrin and pepsinogen C only in HIV-positive patients without AIDS or with a CD4+ count of > 100 x 10(6) cells/L. Atrophy was more frequent in patients with overt AIDS than in those without overt AIDS (57% vs. 33%, P=N.S.), and/or in patients with a CD4+ count of < 100 x 10(6) cells/L than in those with a CD4+ count of > 100 x 10(6) cells/L (62% vs. 26%, P < 0.05). CONCLUSIONS: HIV-positive patients without overt AIDS have increased serum levels of gastrin and pepsinogen C compared with HIV-positive patients with overt AIDS.
BACKGROUND: The relationship between serum parameters of gastric function and Helicobacter pyloriinfection in human immunodeficiency virus (HIV)-positivepatients is almost unknown. AIMS: To investigate in HIV-infectedpatients: (i) the relationship between serum gastrin and serum pepsinogens over the progressive phases of HIV-related disease; (ii) the impact of H. pyloriinfection on gastrin and pepsinogen serum levels and its relation to antral histology; (iii) the prevalence of parietal cell autoantibodies. METHODS: Fifty-nine HIV-positive patients were studied by upper endoscopy plus gastric antral biopsy. Serum samples were tested for gastrin, pepsinogen A, pepsinogen C and parietal cell autoantibodies. RESULTS: In patients without overt acquired immunodeficiency syndrome (AIDS), or with a CD4+ count of > 100 x 10(6) cells/L, mean serum levels of gastrin and pepsinogen C were higher than in subjects with AIDS or with a CD4+ count of < 100 x 10(6) cells/L (P < 0.01). Only one patient was found to be positive for parietal cell autoantibodies. H. pyloriinfection was associated with increased values of gastrin and pepsinogen C only in HIV-positive patients without AIDS or with a CD4+ count of > 100 x 10(6) cells/L. Atrophy was more frequent in patients with overt AIDS than in those without overt AIDS (57% vs. 33%, P=N.S.), and/or in patients with a CD4+ count of < 100 x 10(6) cells/L than in those with a CD4+ count of > 100 x 10(6) cells/L (62% vs. 26%, P < 0.05). CONCLUSIONS:HIV-positive patients without overt AIDS have increased serum levels of gastrin and pepsinogen C compared with HIV-positive patients with overt AIDS.
Authors: T Fukui; A Nishio; K Okazaki; N Uza; S Ueno; M Kido; S Inoue; H Kitamura; K Kiriya; S Ohashi; M Asada; H Tamaki; M Matsuura; K Kawasaki; K Suzuki; K Uchida; H Fukui; H Nakase; N Watanabe; T Chiba Journal: Gut Date: 2005-12-01 Impact factor: 23.059
Authors: Andréa B C Fialho; Manuel B Braga-Neto; Eder J C Guerra; André M N Fialho; Karine C Fernandes; Juliana L M Sun; Christianne F V Takeda; Cícero I S Silva; Dulciene M M Queiroz; Lucia L B C Braga Journal: BMC Gastroenterol Date: 2011-02-19 Impact factor: 3.067
Authors: Joe Geraghty; Alexander Thumbs; Anstead Kankwatira; Tim Andrews; Andrew Moore; Rose Malamba; Neema Mtunthama; Kai Hellberg; Lughano Kalongolera; Paul O'Toole; Andrea Varro; D Mark Pritchard; Melita Gordon Journal: PLoS One Date: 2015-08-05 Impact factor: 3.240