Literature DB >> 8517712

In vitro susceptibility of Helicobacter pylori to several antimicrobial combinations.

M J Pavicić1, F Namavar, T Verboom, A J van Winkelhoff, J De Graaff.   

Abstract

Synergy between metronidazole and its hydroxymetabolite and between each compound and amoxicillin or tetracycline-HCl was determined against Helicobacter pylori. Metronidazole plus its hydroxymetabolite and either compound combined with amoxicillin showed synergism against all 10 strains of H. pylori tested. Metronidazole plus tetracycline-HCl or the hydroxymetabolite plus tetracycline-HCl acted synergistically against seven and six strains, respectively, acted additively against three strains, and had no additional effect against one strain. These results may help to explain the in vivo efficacies of metronidazole combinations in the treatment of H. pylori-associated gastritis.

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Year:  1993        PMID： 8517712      PMCID： PMC187929          DOI： 10.1128/AAC.37.5.1184

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Activity of metronidazole and its hydroxy metabolite against clinical isolates of Actinobacillus actinomycetemcomitans.

Authors:  H Jousimies-Somer; S Asikainen; P Suomala; P Summanen
Journal:  Oral Microbiol Immunol       Date:  1988-03

2.  Campylobacter pyloridis--a new factor in peptic ulcer disease?

Authors:  B J Rathbone; J I Wyatt; R V Heatley
Journal:  Gut       Date:  1986-06       Impact factor: 23.059

3.  Unidentified curved bacilli on gastric epithelium in active chronic gastritis.

Authors:  J R Warren; B Marshall
Journal:  Lancet       Date:  1983-06-04       Impact factor: 79.321

4.  A method for testing for synergy with any number of agents.

Authors:  M C Berenbaum
Journal:  J Infect Dis       Date:  1978-02       Impact factor: 5.226

5.  Determination of metronidazole and its two major metabolites in biological fluids by high pressure liquid chromatography.

Authors:  A Gulaid; G W Houghton; O R Lewellen; J Smith; P S Thorne
Journal:  Br J Clin Pharmacol       Date:  1978-11       Impact factor: 4.335

6.  Adjuvant antibiotic therapy in duodenal ulcers treated with colloidal bismuth subcitrate.

Authors:  T O'Riordan; E Mathai; E Tobin; D McKenna; C Keane; E Sweeney; C O'Morain
Journal:  Gut       Date:  1990-09       Impact factor: 23.059

7.  Characterization of metronidazole metabolism by human liver microsomes.

Authors:  S Loft; S V Otton; M S Lennard; G T Tucker; H E Poulsen
Journal:  Biochem Pharmacol       Date:  1991-04-15       Impact factor: 5.858

8.  Bactericidal effect of amoxicillin on Helicobacter pylori in an in vitro model using epithelial cells.

Authors:  F Megraud; H Lamouliatte; L Boyanova
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

9.  Cure of duodenal ulcer associated with eradication of Helicobacter pylori.

Authors:  E A Rauws; G N Tytgat
Journal:  Lancet       Date:  1990-05-26       Impact factor: 79.321

10.  In vitro activity of the two principal oxidative metabolites of metronidazole against Bacteroides fragilis and related species.

Authors:  I Haller
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191
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  8 in total

1.  In vitro activity of omeprazole in combination with several antimicrobial agents against clinical isolates of Helicobacter pylori.

Authors:  T Alarcón; D Domingo; I Sánchez; F Díaz de Rojas; M López-Brea
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1996-12       Impact factor: 3.267

2.  Effects of metronidazole, tetracycline, and bismuth-metronidazole-tetracycline triple therapy in the Helicobacter pylori SS1 mouse model after 1 day of dosing: development of an H. pylori lead selection model.

Authors:  Christine F Sizemore; Joel D Quispe; Karen M Amsler; Todd C Modzelewski; Jayson J Merrill; D Andrew Stevenson; Lorie A Foster; Andrew M Slee
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

3.  Comparison of different criteria for interpretation of immunoglobulin G immunoblotting results for diagnosis of Helicobacter pylori infection.

Authors:  Philipp M Lepper; Angelika Möricke; Konstanze Vogt; Günter Bode; Matthias Trautmann
Journal:  Clin Diagn Lab Immunol       Date:  2004-05

4.  Standardization of disk diffusion test and its clinical significance for susceptibility testing of metronidazole against Helicobacter pylori.

Authors:  H Xia; C T Keane; S Beattie; C A O'Morain
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

5.  Use of time-kill methodology to assess antimicrobial combinations against metronidazole-susceptible and metronidazole-resistant strains of Helicobacter pylori.

Authors:  P E Coudron; C W Stratton
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

6.  A low prevalence of H pylori and endoscopic findings in HIV-positive Chinese patients with gastrointestinal symptoms.

Authors:  Fu-Jing Lv; Xiao-Lan Luo; Xin Meng; Rui Jin; Hui-Guo Ding; Shu-Tian Zhang
Journal:  World J Gastroenterol       Date:  2007-11-07       Impact factor: 5.742

7.  Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan.

Authors:  I-Ting Wu; Seng-Kee Chuah; Chen-Hsiang Lee; Chih-Ming Liang; Lung-Sheng Lu; Yuan-Hung Kuo; Yi-Hao Yen; Ming-Luen Hu; Yeh-Pin Chou; Shih-Cheng Yang; Chung-Mou Kuo; Chung-Huang Kuo; Chun-Chih Chien; Yu-Shao Chiang; Shue-Shian Chiou; Tsung-Hui Hu; Wei-Chen Tai
Journal:  World J Gastroenterol       Date:  2015-10-07       Impact factor: 5.742

8.  Long-term colonization with single and multiple strains of Helicobacter pylori assessed by DNA fingerprinting.

Authors:  N S Taylor; J G Fox; N S Akopyants; D E Berg; N Thompson; B Shames; L Yan; E Fontham; F Janney; F M Hunter
Journal:  J Clin Microbiol       Date:  1995-04       Impact factor: 5.948
  8 in total

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